An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys

BACKGROUND: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the ex...

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Autores principales: Cano, Jorge, Moraga, Paula, Nikolay, Birgit, Rebollo, Maria P., Okorie, Patricia N., Davies, Emmanuel, Njenga, Sammy M., Bockarie, Moses J., Brooker, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542699/
https://www.ncbi.nlm.nih.gov/pubmed/26101292
http://dx.doi.org/10.1093/trstmh/trv048
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author Cano, Jorge
Moraga, Paula
Nikolay, Birgit
Rebollo, Maria P.
Okorie, Patricia N.
Davies, Emmanuel
Njenga, Sammy M.
Bockarie, Moses J.
Brooker, Simon J.
author_facet Cano, Jorge
Moraga, Paula
Nikolay, Birgit
Rebollo, Maria P.
Okorie, Patricia N.
Davies, Emmanuel
Njenga, Sammy M.
Bockarie, Moses J.
Brooker, Simon J.
author_sort Cano, Jorge
collection PubMed
description BACKGROUND: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known. METHODS: This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures. RESULTS AND CONCLUSIONS: In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.
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spelling pubmed-45426992015-08-25 An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys Cano, Jorge Moraga, Paula Nikolay, Birgit Rebollo, Maria P. Okorie, Patricia N. Davies, Emmanuel Njenga, Sammy M. Bockarie, Moses J. Brooker, Simon J. Trans R Soc Trop Med Hyg Short Communications BACKGROUND: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known. METHODS: This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures. RESULTS AND CONCLUSIONS: In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed. Oxford University Press 2015-08 2015-06-21 /pmc/articles/PMC4542699/ /pubmed/26101292 http://dx.doi.org/10.1093/trstmh/trv048 Text en © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Cano, Jorge
Moraga, Paula
Nikolay, Birgit
Rebollo, Maria P.
Okorie, Patricia N.
Davies, Emmanuel
Njenga, Sammy M.
Bockarie, Moses J.
Brooker, Simon J.
An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys
title An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys
title_full An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys
title_fullStr An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys
title_full_unstemmed An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys
title_short An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys
title_sort investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542699/
https://www.ncbi.nlm.nih.gov/pubmed/26101292
http://dx.doi.org/10.1093/trstmh/trv048
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