Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes

This review provides an overview of two complementary approaches to identify biologically active compounds for studies in chemical ecology. The first is activity-guided fractionation and the second is metabolomics, particularly focusing on a new liquid chromatography–mass spectrometry-based method c...

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Detalles Bibliográficos
Autores principales: Edison, Arthur S., Clendinen, Chaevien S., Ajredini, Ramadan, Beecher, Chris, Ponce, Francesca V., Stupp, Gregory S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Chemicals that Organize Ecology: Towards a Greater Integration of Chemoreception, Neuroscience, Organismal Biology, and Chemical Ecology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543130/
https://www.ncbi.nlm.nih.gov/pubmed/26141866
http://dx.doi.org/10.1093/icb/icv077
Descripción
Sumario:This review provides an overview of two complementary approaches to identify biologically active compounds for studies in chemical ecology. The first is activity-guided fractionation and the second is metabolomics, particularly focusing on a new liquid chromatography–mass spectrometry-based method called isotopic ratio outlier analysis. To illustrate examples using these approaches, we review recent experiments using Caenorhabditis elegans and related free-living nematodes.

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