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Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes
This review provides an overview of two complementary approaches to identify biologically active compounds for studies in chemical ecology. The first is activity-guided fractionation and the second is metabolomics, particularly focusing on a new liquid chromatography–mass spectrometry-based method c...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543130/ https://www.ncbi.nlm.nih.gov/pubmed/26141866 http://dx.doi.org/10.1093/icb/icv077 |
| _version_ | 1782386577963483136 |
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| author | Edison, Arthur S. Clendinen, Chaevien S. Ajredini, Ramadan Beecher, Chris Ponce, Francesca V. Stupp, Gregory S. |
| author_facet | Edison, Arthur S. Clendinen, Chaevien S. Ajredini, Ramadan Beecher, Chris Ponce, Francesca V. Stupp, Gregory S. |
| author_sort | Edison, Arthur S. |
| collection | PubMed |
| description | This review provides an overview of two complementary approaches to identify biologically active compounds for studies in chemical ecology. The first is activity-guided fractionation and the second is metabolomics, particularly focusing on a new liquid chromatography–mass spectrometry-based method called isotopic ratio outlier analysis. To illustrate examples using these approaches, we review recent experiments using Caenorhabditis elegans and related free-living nematodes. |
| format | Online Article Text |
| id | pubmed-4543130 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-45431302015-08-25 Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes Edison, Arthur S. Clendinen, Chaevien S. Ajredini, Ramadan Beecher, Chris Ponce, Francesca V. Stupp, Gregory S. Integr Comp Biol Chemicals that Organize Ecology: Towards a Greater Integration of Chemoreception, Neuroscience, Organismal Biology, and Chemical Ecology This review provides an overview of two complementary approaches to identify biologically active compounds for studies in chemical ecology. The first is activity-guided fractionation and the second is metabolomics, particularly focusing on a new liquid chromatography–mass spectrometry-based method called isotopic ratio outlier analysis. To illustrate examples using these approaches, we review recent experiments using Caenorhabditis elegans and related free-living nematodes. Oxford University Press 2015-09 2015-07-02 /pmc/articles/PMC4543130/ /pubmed/26141866 http://dx.doi.org/10.1093/icb/icv077 Text en © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Chemicals that Organize Ecology: Towards a Greater Integration of Chemoreception, Neuroscience, Organismal Biology, and Chemical Ecology Edison, Arthur S. Clendinen, Chaevien S. Ajredini, Ramadan Beecher, Chris Ponce, Francesca V. Stupp, Gregory S. Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes |
| title | Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes |
| title_full | Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes |
| title_fullStr | Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes |
| title_full_unstemmed | Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes |
| title_short | Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes |
| title_sort | metabolomics and natural-products strategies to study chemical ecology in nematodes |
| topic | Chemicals that Organize Ecology: Towards a Greater Integration of Chemoreception, Neuroscience, Organismal Biology, and Chemical Ecology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543130/ https://www.ncbi.nlm.nih.gov/pubmed/26141866 http://dx.doi.org/10.1093/icb/icv077 |
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