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Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation
BACKGROUND: Human leukocyte antigen (HLA)-B*5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*5701 prevalence in HIV-1-infected subjects in China. We investigated HLA-B*5701 prevalence in HIV-1-infected population including Han and...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543466/ https://www.ncbi.nlm.nih.gov/pubmed/26300948 http://dx.doi.org/10.1186/s12981-015-0064-9 |
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author | Zhang, Hongwei Zhang, Tong Zhao, Hongxin Han, Ning Zhou, Haiwei He, Yun Zhao, Qingxia Li, Hong Li, Huiqin Zhang, Mi Li, Jianjian Sun, Yongtao Zhao, Ke Liu, Qing Liu, Zhiying Li, Zhen Xia, Wei Lan, Yun Hu, Haolan Cai, Weiping Wu, Hao |
author_facet | Zhang, Hongwei Zhang, Tong Zhao, Hongxin Han, Ning Zhou, Haiwei He, Yun Zhao, Qingxia Li, Hong Li, Huiqin Zhang, Mi Li, Jianjian Sun, Yongtao Zhao, Ke Liu, Qing Liu, Zhiying Li, Zhen Xia, Wei Lan, Yun Hu, Haolan Cai, Weiping Wu, Hao |
author_sort | Zhang, Hongwei |
collection | PubMed |
description | BACKGROUND: Human leukocyte antigen (HLA)-B*5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*5701 prevalence in HIV-1-infected subjects in China. We investigated HLA-B*5701 prevalence in HIV-1-infected population including Han and non-Han ethnic groups. METHODS: A prospective multi-centre study was designed to determine status of HLA-B*5701 in HIV-1-infected adults at six sites across China. HLA-B*5701 was tested by the method of PCR-SSP. RESULTS: From six centers, 3,000 HIV-infected patients [2,452 (81.7%) Han, 548 (18.3%) Non-Han] were recruited with a mean age of 36.7 years old. The overall HLA-B*5701 prevalence was 0.86% [95% confidence interval (CI) 0.55–1.26%]. The prevalence of HLA-B*5701 among Han subjects was similar to that among non-Han subjects, which was 0.88% (95% CI 0.54–1.34%) and 0.76% (95% CI 0.19–1.93%), respectively (p value = 0.787). There were no differences in prevalence of HLA-B*5701 between subjects born in Henan, Yunnan, Shanxi, Guangdong, Hebei, Beijing and other provinces (p = 0.999). CONCLUSIONS: HLA-B*5701 prevalence is very low in HIV-infected Chinese subjects, both in the Han and Non-Han nationalities. And there are no differences among different birthplaces across China. |
format | Online Article Text |
id | pubmed-4543466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45434662015-08-22 Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation Zhang, Hongwei Zhang, Tong Zhao, Hongxin Han, Ning Zhou, Haiwei He, Yun Zhao, Qingxia Li, Hong Li, Huiqin Zhang, Mi Li, Jianjian Sun, Yongtao Zhao, Ke Liu, Qing Liu, Zhiying Li, Zhen Xia, Wei Lan, Yun Hu, Haolan Cai, Weiping Wu, Hao AIDS Res Ther Research BACKGROUND: Human leukocyte antigen (HLA)-B*5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*5701 prevalence in HIV-1-infected subjects in China. We investigated HLA-B*5701 prevalence in HIV-1-infected population including Han and non-Han ethnic groups. METHODS: A prospective multi-centre study was designed to determine status of HLA-B*5701 in HIV-1-infected adults at six sites across China. HLA-B*5701 was tested by the method of PCR-SSP. RESULTS: From six centers, 3,000 HIV-infected patients [2,452 (81.7%) Han, 548 (18.3%) Non-Han] were recruited with a mean age of 36.7 years old. The overall HLA-B*5701 prevalence was 0.86% [95% confidence interval (CI) 0.55–1.26%]. The prevalence of HLA-B*5701 among Han subjects was similar to that among non-Han subjects, which was 0.88% (95% CI 0.54–1.34%) and 0.76% (95% CI 0.19–1.93%), respectively (p value = 0.787). There were no differences in prevalence of HLA-B*5701 between subjects born in Henan, Yunnan, Shanxi, Guangdong, Hebei, Beijing and other provinces (p = 0.999). CONCLUSIONS: HLA-B*5701 prevalence is very low in HIV-infected Chinese subjects, both in the Han and Non-Han nationalities. And there are no differences among different birthplaces across China. BioMed Central 2015-08-19 /pmc/articles/PMC4543466/ /pubmed/26300948 http://dx.doi.org/10.1186/s12981-015-0064-9 Text en © Zhang et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Zhang, Hongwei Zhang, Tong Zhao, Hongxin Han, Ning Zhou, Haiwei He, Yun Zhao, Qingxia Li, Hong Li, Huiqin Zhang, Mi Li, Jianjian Sun, Yongtao Zhao, Ke Liu, Qing Liu, Zhiying Li, Zhen Xia, Wei Lan, Yun Hu, Haolan Cai, Weiping Wu, Hao Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation |
title | Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation |
title_full | Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation |
title_fullStr | Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation |
title_full_unstemmed | Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation |
title_short | Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation |
title_sort | low prevalence of human leukocyte antigen-b*5701 in hiv-1-infected chinese subjects: a prospective epidemiological investigation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543466/ https://www.ncbi.nlm.nih.gov/pubmed/26300948 http://dx.doi.org/10.1186/s12981-015-0064-9 |
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