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Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance

Evaluating whether a new medication prolongs QT intervals is a critical safety activity that is conducted in a sensitive animal model during non-clinical drug development. The importance of QT liability detection has been reinforced by non-clinical [International Conference on Harmonization (ICH) S7...

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Detalles Bibliográficos
Autores principales:	Vargas, Hugo M, Bass, Alan S, Koerner, John, Matis-Mitchell, Sherri, Pugsley, Michael K, Skinner, Matthew, Burnham, Matthew, Bridgland-Taylor, Matthew, Pettit, Syril, Valentin, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543608/ https://www.ncbi.nlm.nih.gov/pubmed/26031452 http://dx.doi.org/10.1111/bph.13207

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