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Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH(4)) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH(4) restores vascular function in patients. Unfortunately, oral BH(4) has limited efficacy. Therefore, orally bi...

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Detalles Bibliográficos
Autores principales:	Hussein, D, Starr, A, Heikal, L, McNeill, E, Channon, K M, Brown, P R, Sutton, B J, McDonnell, J M, Nandi, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543619/ https://www.ncbi.nlm.nih.gov/pubmed/26014146 http://dx.doi.org/10.1111/bph.13202

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