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Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects

The tumor suppressor liver kinase B1 (LKB1) is an important regulator of pancreatic β cell biology. LKB1-dependent phosphorylation of distinct AMPK (adenosine monophosphate-activated protein kinase) family members determines proper β cell polarity and restricts β cell size, total β cell mass, and gl...

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Detalles Bibliográficos
Autores principales:	Swisa, Avital, Granot, Zvi, Tamarina, Natalia, Sayers, Sophie, Bardeesy, Nabeel, Philipson, Louis, Hodson, David J., Wikstrom, Jakob D., Rutter, Guy A., Leibowitz, Gil, Glaser, Benjamin, Dor, Yuval
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543653/ https://www.ncbi.nlm.nih.gov/pubmed/26139601 http://dx.doi.org/10.1074/jbc.M115.639237

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