Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis

AIMS: Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are powerful regulators of gene expression and thus might mediate this process. METHODS AND RESULTS: OPN and miR-21 were significantly inc...

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Detalles Bibliográficos
Autores principales: Lorenzen, Johan M., Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K., Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A., Weidemann, Frank, Müller, Oliver J., Haller, Hermann, Thum, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543785/
https://www.ncbi.nlm.nih.gov/pubmed/25898844
http://dx.doi.org/10.1093/eurheartj/ehv109

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