Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model

Peptidyl arginine deiminase 4 (PAD4) is an enzyme that is involved in protein citrullination, and is a target for anti-citrullinated peptide antibodies (ACPAs) in rheumatoid arthritis (RA). Genetic polymorphisms in the PADI4 gene encoding PAD4 are associated with RA susceptibility. We herein analyze...

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Detalles Bibliográficos
Autores principales: Seri, Yu, Shoda, Hirofumi, Suzuki, Akari, Matsumoto, Isao, Sumida, Takayuki, Fujio, Keishi, Yamamoto, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544002/
https://www.ncbi.nlm.nih.gov/pubmed/26293116
http://dx.doi.org/10.1038/srep13041

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