Cargando…
Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn
Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery. However, a serious adverse effect of TXA is seizure due to inhibition of γ-aminobutyric acid (GABA) and glycine receptors in cortical neurons. These receptors are also present in the spinal cord, and...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544020/ https://www.ncbi.nlm.nih.gov/pubmed/26293582 http://dx.doi.org/10.1038/srep13458 |
_version_ | 1782386637019283456 |
---|---|
author | Ohashi, Nobuko Sasaki, Mika Ohashi, Masayuki Kamiya, Yoshinori Baba, Hiroshi Kohno, Tatsuro |
author_facet | Ohashi, Nobuko Sasaki, Mika Ohashi, Masayuki Kamiya, Yoshinori Baba, Hiroshi Kohno, Tatsuro |
author_sort | Ohashi, Nobuko |
collection | PubMed |
description | Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery. However, a serious adverse effect of TXA is seizure due to inhibition of γ-aminobutyric acid (GABA) and glycine receptors in cortical neurons. These receptors are also present in the spinal cord, and antagonism of these receptors in spinal dorsal horn neurons produces pain-related phenomena, such as allodynia and hyperalgesia, in experimental animals. Moreover, some patients who are injected intrathecally with TXA develop severe back pain. However, the effect of TXA on spinal dorsal horn neurons remain poorly understood. Here, we investigated the effects of TXA by using behavioral measures in rats and found that TXA produces behaviors indicative of spontaneous pain and mechanical allodynia. We then performed whole-cell patch-clamp experiments that showed that TXA inhibits GABA(A) and glycine receptors in spinal dorsal horn neurons. Finally, we also showed that TXA facilitates activation of the extracellular signal-regulated kinase in the spinal cord. These results indicated that TXA produces pain by inhibiting GABA(A) and glycine receptors in the spinal dorsal horn. |
format | Online Article Text |
id | pubmed-4544020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45440202015-09-01 Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn Ohashi, Nobuko Sasaki, Mika Ohashi, Masayuki Kamiya, Yoshinori Baba, Hiroshi Kohno, Tatsuro Sci Rep Article Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery. However, a serious adverse effect of TXA is seizure due to inhibition of γ-aminobutyric acid (GABA) and glycine receptors in cortical neurons. These receptors are also present in the spinal cord, and antagonism of these receptors in spinal dorsal horn neurons produces pain-related phenomena, such as allodynia and hyperalgesia, in experimental animals. Moreover, some patients who are injected intrathecally with TXA develop severe back pain. However, the effect of TXA on spinal dorsal horn neurons remain poorly understood. Here, we investigated the effects of TXA by using behavioral measures in rats and found that TXA produces behaviors indicative of spontaneous pain and mechanical allodynia. We then performed whole-cell patch-clamp experiments that showed that TXA inhibits GABA(A) and glycine receptors in spinal dorsal horn neurons. Finally, we also showed that TXA facilitates activation of the extracellular signal-regulated kinase in the spinal cord. These results indicated that TXA produces pain by inhibiting GABA(A) and glycine receptors in the spinal dorsal horn. Nature Publishing Group 2015-08-21 /pmc/articles/PMC4544020/ /pubmed/26293582 http://dx.doi.org/10.1038/srep13458 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Ohashi, Nobuko Sasaki, Mika Ohashi, Masayuki Kamiya, Yoshinori Baba, Hiroshi Kohno, Tatsuro Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn |
title | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn |
title_full | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn |
title_fullStr | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn |
title_full_unstemmed | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn |
title_short | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn |
title_sort | tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544020/ https://www.ncbi.nlm.nih.gov/pubmed/26293582 http://dx.doi.org/10.1038/srep13458 |
work_keys_str_mv | AT ohashinobuko tranexamicacidevokespainbymodulatingneuronalexcitabilityinthespinaldorsalhorn AT sasakimika tranexamicacidevokespainbymodulatingneuronalexcitabilityinthespinaldorsalhorn AT ohashimasayuki tranexamicacidevokespainbymodulatingneuronalexcitabilityinthespinaldorsalhorn AT kamiyayoshinori tranexamicacidevokespainbymodulatingneuronalexcitabilityinthespinaldorsalhorn AT babahiroshi tranexamicacidevokespainbymodulatingneuronalexcitabilityinthespinaldorsalhorn AT kohnotatsuro tranexamicacidevokespainbymodulatingneuronalexcitabilityinthespinaldorsalhorn |