Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn

Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery. However, a serious adverse effect of TXA is seizure due to inhibition of γ-aminobutyric acid (GABA) and glycine receptors in cortical neurons. These receptors are also present in the spinal cord, and...

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Detalles Bibliográficos
Autores principales: Ohashi, Nobuko, Sasaki, Mika, Ohashi, Masayuki, Kamiya, Yoshinori, Baba, Hiroshi, Kohno, Tatsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544020/
https://www.ncbi.nlm.nih.gov/pubmed/26293582
http://dx.doi.org/10.1038/srep13458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544020/
https://www.ncbi.nlm.nih.gov/pubmed/26293582
http://dx.doi.org/10.1038/srep13458

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