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Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn

Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery. However, a serious adverse effect of TXA is seizure due to inhibition of γ-aminobutyric acid (GABA) and glycine receptors in cortical neurons. These receptors are also present in the spinal cord, and...

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Detalles Bibliográficos
Autores principales:	Ohashi, Nobuko, Sasaki, Mika, Ohashi, Masayuki, Kamiya, Yoshinori, Baba, Hiroshi, Kohno, Tatsuro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544020/ https://www.ncbi.nlm.nih.gov/pubmed/26293582 http://dx.doi.org/10.1038/srep13458

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