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LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN
The aims of this study were to compare the detection of human herpesviruses (HHVs) in the saliva of HIV-infected and healthy control children, and to evaluate associations between viral infection and gingivitis and immunodeficiency. Saliva samples were collected from 48 HIV-infected and 48 healthy c...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Revista do Instituto de Medicina Tropical de São Paulo
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544246/ https://www.ncbi.nlm.nih.gov/pubmed/26200962 http://dx.doi.org/10.1590/S0036-46652015000300007 |
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author | OTERO, Renata A. NASCIMENTO, Flávia N.N. SOUZA, Ivete P.R. SILVA, Raquel C. LIMA, Rodrigo S. ROBAINA, Tatiana F. CÂMARA, Fernando P. SANTOS, Norma CASTRO, Gloria F. |
author_facet | OTERO, Renata A. NASCIMENTO, Flávia N.N. SOUZA, Ivete P.R. SILVA, Raquel C. LIMA, Rodrigo S. ROBAINA, Tatiana F. CÂMARA, Fernando P. SANTOS, Norma CASTRO, Gloria F. |
author_sort | OTERO, Renata A. |
collection | PubMed |
description | The aims of this study were to compare the detection of human herpesviruses (HHVs) in the saliva of HIV-infected and healthy control children, and to evaluate associations between viral infection and gingivitis and immunodeficiency. Saliva samples were collected from 48 HIV-infected and 48 healthy control children. Clinical and laboratory data were collected during dental visits and from medical records. A trained dentist determined gingival indices and extension of gingivitis. Saliva samples were tested for herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) by nested polymerase chain reaction assays. Thirty-five HIV-infected and 16 control children had gingivitis. Seventeen (35.4%) HIV-infected children and 13 (27%) control children were positive for HHVs. CMV was the most commonly detected HHV in both groups (HIV-infected, 25%; control, 12.5%), followed by HSV-1 (6.2% in both groups) and HSV-2 (HIV-infected, 4.2%; control, 8.3%). The presence of HHVs in saliva was not associated with the presence of gingivitis in HIV-1-infected children (p = 0.104) or healthy control children (p = 0.251), or with immunosuppression in HIV-infected individuals (p = 0.447). Gingivitis was correlated with HIV infection (p = 0.0001). These results suggest that asymptomatic salivary detection of HHVs is common in HIV-infected and healthy children, and that it is not associated with gingivitis. |
format | Online Article Text |
id | pubmed-4544246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Revista do Instituto de Medicina Tropical de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-45442462015-08-25 LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN OTERO, Renata A. NASCIMENTO, Flávia N.N. SOUZA, Ivete P.R. SILVA, Raquel C. LIMA, Rodrigo S. ROBAINA, Tatiana F. CÂMARA, Fernando P. SANTOS, Norma CASTRO, Gloria F. Rev Inst Med Trop Sao Paulo Virology The aims of this study were to compare the detection of human herpesviruses (HHVs) in the saliva of HIV-infected and healthy control children, and to evaluate associations between viral infection and gingivitis and immunodeficiency. Saliva samples were collected from 48 HIV-infected and 48 healthy control children. Clinical and laboratory data were collected during dental visits and from medical records. A trained dentist determined gingival indices and extension of gingivitis. Saliva samples were tested for herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) by nested polymerase chain reaction assays. Thirty-five HIV-infected and 16 control children had gingivitis. Seventeen (35.4%) HIV-infected children and 13 (27%) control children were positive for HHVs. CMV was the most commonly detected HHV in both groups (HIV-infected, 25%; control, 12.5%), followed by HSV-1 (6.2% in both groups) and HSV-2 (HIV-infected, 4.2%; control, 8.3%). The presence of HHVs in saliva was not associated with the presence of gingivitis in HIV-1-infected children (p = 0.104) or healthy control children (p = 0.251), or with immunosuppression in HIV-infected individuals (p = 0.447). Gingivitis was correlated with HIV infection (p = 0.0001). These results suggest that asymptomatic salivary detection of HHVs is common in HIV-infected and healthy children, and that it is not associated with gingivitis. Revista do Instituto de Medicina Tropical de São Paulo 2015 /pmc/articles/PMC4544246/ /pubmed/26200962 http://dx.doi.org/10.1590/S0036-46652015000300007 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Virology OTERO, Renata A. NASCIMENTO, Flávia N.N. SOUZA, Ivete P.R. SILVA, Raquel C. LIMA, Rodrigo S. ROBAINA, Tatiana F. CÂMARA, Fernando P. SANTOS, Norma CASTRO, Gloria F. LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN |
title | LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND
GINGIVITIS IN HIV‑INFECTED CHILDREN |
title_full | LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND
GINGIVITIS IN HIV‑INFECTED CHILDREN |
title_fullStr | LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND
GINGIVITIS IN HIV‑INFECTED CHILDREN |
title_full_unstemmed | LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND
GINGIVITIS IN HIV‑INFECTED CHILDREN |
title_short | LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND
GINGIVITIS IN HIV‑INFECTED CHILDREN |
title_sort | lack of association between herpesvirus detection in saliva and
gingivitis in hiv‑infected children |
topic | Virology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544246/ https://www.ncbi.nlm.nih.gov/pubmed/26200962 http://dx.doi.org/10.1590/S0036-46652015000300007 |
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