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LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN

The aims of this study were to compare the detection of human herpesviruses (HHVs) in the saliva of HIV-infected and healthy control children, and to evaluate associations between viral infection and gingivitis and immunodeficiency. Saliva samples were collected from 48 HIV-infected and 48 healthy c...

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Autores principales: OTERO, Renata A., NASCIMENTO, Flávia N.N., SOUZA, Ivete P.R., SILVA, Raquel C., LIMA, Rodrigo S., ROBAINA, Tatiana F., CÂMARA, Fernando P., SANTOS, Norma, CASTRO, Gloria F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Revista do Instituto de Medicina Tropical de São Paulo 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544246/
https://www.ncbi.nlm.nih.gov/pubmed/26200962
http://dx.doi.org/10.1590/S0036-46652015000300007
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author OTERO, Renata A.
NASCIMENTO, Flávia N.N.
SOUZA, Ivete P.R.
SILVA, Raquel C.
LIMA, Rodrigo S.
ROBAINA, Tatiana F.
CÂMARA, Fernando P.
SANTOS, Norma
CASTRO, Gloria F.
author_facet OTERO, Renata A.
NASCIMENTO, Flávia N.N.
SOUZA, Ivete P.R.
SILVA, Raquel C.
LIMA, Rodrigo S.
ROBAINA, Tatiana F.
CÂMARA, Fernando P.
SANTOS, Norma
CASTRO, Gloria F.
author_sort OTERO, Renata A.
collection PubMed
description The aims of this study were to compare the detection of human herpesviruses (HHVs) in the saliva of HIV-infected and healthy control children, and to evaluate associations between viral infection and gingivitis and immunodeficiency. Saliva samples were collected from 48 HIV-infected and 48 healthy control children. Clinical and laboratory data were collected during dental visits and from medical records. A trained dentist determined gingival indices and extension of gingivitis. Saliva samples were tested for herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) by nested polymerase chain reaction assays. Thirty-five HIV-infected and 16 control children had gingivitis. Seventeen (35.4%) HIV-infected children and 13 (27%) control children were positive for HHVs. CMV was the most commonly detected HHV in both groups (HIV-infected, 25%; control, 12.5%), followed by HSV-1 (6.2% in both groups) and HSV-2 (HIV-infected, 4.2%; control, 8.3%). The presence of HHVs in saliva was not associated with the presence of gingivitis in HIV-1-infected children (p = 0.104) or healthy control children (p = 0.251), or with immunosuppression in HIV-infected individuals (p = 0.447). Gingivitis was correlated with HIV infection (p = 0.0001). These results suggest that asymptomatic salivary detection of HHVs is common in HIV-infected and healthy children, and that it is not associated with gingivitis.
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spelling pubmed-45442462015-08-25 LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN OTERO, Renata A. NASCIMENTO, Flávia N.N. SOUZA, Ivete P.R. SILVA, Raquel C. LIMA, Rodrigo S. ROBAINA, Tatiana F. CÂMARA, Fernando P. SANTOS, Norma CASTRO, Gloria F. Rev Inst Med Trop Sao Paulo Virology The aims of this study were to compare the detection of human herpesviruses (HHVs) in the saliva of HIV-infected and healthy control children, and to evaluate associations between viral infection and gingivitis and immunodeficiency. Saliva samples were collected from 48 HIV-infected and 48 healthy control children. Clinical and laboratory data were collected during dental visits and from medical records. A trained dentist determined gingival indices and extension of gingivitis. Saliva samples were tested for herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) by nested polymerase chain reaction assays. Thirty-five HIV-infected and 16 control children had gingivitis. Seventeen (35.4%) HIV-infected children and 13 (27%) control children were positive for HHVs. CMV was the most commonly detected HHV in both groups (HIV-infected, 25%; control, 12.5%), followed by HSV-1 (6.2% in both groups) and HSV-2 (HIV-infected, 4.2%; control, 8.3%). The presence of HHVs in saliva was not associated with the presence of gingivitis in HIV-1-infected children (p = 0.104) or healthy control children (p = 0.251), or with immunosuppression in HIV-infected individuals (p = 0.447). Gingivitis was correlated with HIV infection (p = 0.0001). These results suggest that asymptomatic salivary detection of HHVs is common in HIV-infected and healthy children, and that it is not associated with gingivitis. Revista do Instituto de Medicina Tropical de São Paulo 2015 /pmc/articles/PMC4544246/ /pubmed/26200962 http://dx.doi.org/10.1590/S0036-46652015000300007 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Virology
OTERO, Renata A.
NASCIMENTO, Flávia N.N.
SOUZA, Ivete P.R.
SILVA, Raquel C.
LIMA, Rodrigo S.
ROBAINA, Tatiana F.
CÂMARA, Fernando P.
SANTOS, Norma
CASTRO, Gloria F.
LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN
title LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN
title_full LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN
title_fullStr LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN
title_full_unstemmed LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN
title_short LACK OF ASSOCIATION BETWEEN HERPESVIRUS DETECTION IN SALIVA AND GINGIVITIS IN HIV‑INFECTED CHILDREN
title_sort lack of association between herpesvirus detection in saliva and gingivitis in hiv‑infected children
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544246/
https://www.ncbi.nlm.nih.gov/pubmed/26200962
http://dx.doi.org/10.1590/S0036-46652015000300007
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