Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats

Estrogen deficiency alters quality of life during menopause. Hormone replacement therapy has been used to improve quality of life and prevent complications, but side effects limit its use. In this study, we evaluated the use of edible bird’s nest (EBN) for prevention of cardiometabolic problems in r...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Zhiping, Imam, Mustapha Umar, Ismail, Maznah, Ooi, Der Jiun, Ideris, Aini, Mahmud, Rozi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544723/
https://www.ncbi.nlm.nih.gov/pubmed/26316695
http://dx.doi.org/10.2147/DDDT.S80743
_version_ 1782386706376294400
author Hou, Zhiping
Imam, Mustapha Umar
Ismail, Maznah
Ooi, Der Jiun
Ideris, Aini
Mahmud, Rozi
author_facet Hou, Zhiping
Imam, Mustapha Umar
Ismail, Maznah
Ooi, Der Jiun
Ideris, Aini
Mahmud, Rozi
author_sort Hou, Zhiping
collection PubMed
description Estrogen deficiency alters quality of life during menopause. Hormone replacement therapy has been used to improve quality of life and prevent complications, but side effects limit its use. In this study, we evaluated the use of edible bird’s nest (EBN) for prevention of cardiometabolic problems in rats with ovariectomy-induced menopause. Ovariectomized female rats were fed for 12 weeks with normal rat chow, EBN, or estrogen and compared with normal non-ovariectomized rats. Metabolic indices (insulin, estrogen, superoxide dismutase, malondialdehyde, oral glucose tolerance test, and lipid profile) were measured at the end of the experiment from serum and liver tissue homogenate, and transcriptional levels of hepatic insulin signaling genes were measured. The results showed that ovariectomy worsened metabolic indices and disrupted the normal transcriptional pattern of hepatic insulin signaling genes. EBN improved the metabolic indices and also produced transcriptional changes in hepatic insulin signaling genes that tended toward enhanced insulin sensitivity, and glucose and lipid homeostasis, even better than estrogen. The data suggest that EBN could meliorate estrogen deficiency-associated increase in risk of cardiometabolic disease in rats, and may in fact be useful as a functional food for the prevention of such a problem in humans. The clinical validity of these findings is worth studying further.
format Online
Article
Text
id pubmed-4544723
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-45447232015-08-27 Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats Hou, Zhiping Imam, Mustapha Umar Ismail, Maznah Ooi, Der Jiun Ideris, Aini Mahmud, Rozi Drug Des Devel Ther Original Research Estrogen deficiency alters quality of life during menopause. Hormone replacement therapy has been used to improve quality of life and prevent complications, but side effects limit its use. In this study, we evaluated the use of edible bird’s nest (EBN) for prevention of cardiometabolic problems in rats with ovariectomy-induced menopause. Ovariectomized female rats were fed for 12 weeks with normal rat chow, EBN, or estrogen and compared with normal non-ovariectomized rats. Metabolic indices (insulin, estrogen, superoxide dismutase, malondialdehyde, oral glucose tolerance test, and lipid profile) were measured at the end of the experiment from serum and liver tissue homogenate, and transcriptional levels of hepatic insulin signaling genes were measured. The results showed that ovariectomy worsened metabolic indices and disrupted the normal transcriptional pattern of hepatic insulin signaling genes. EBN improved the metabolic indices and also produced transcriptional changes in hepatic insulin signaling genes that tended toward enhanced insulin sensitivity, and glucose and lipid homeostasis, even better than estrogen. The data suggest that EBN could meliorate estrogen deficiency-associated increase in risk of cardiometabolic disease in rats, and may in fact be useful as a functional food for the prevention of such a problem in humans. The clinical validity of these findings is worth studying further. Dove Medical Press 2015-08-14 /pmc/articles/PMC4544723/ /pubmed/26316695 http://dx.doi.org/10.2147/DDDT.S80743 Text en © 2015 Hou et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Hou, Zhiping
Imam, Mustapha Umar
Ismail, Maznah
Ooi, Der Jiun
Ideris, Aini
Mahmud, Rozi
Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
title Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
title_full Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
title_fullStr Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
title_full_unstemmed Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
title_short Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
title_sort nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544723/
https://www.ncbi.nlm.nih.gov/pubmed/26316695
http://dx.doi.org/10.2147/DDDT.S80743
work_keys_str_mv AT houzhiping nutrigenomiceffectsofediblebirdsnestoninsulinsignalinginovariectomizedrats
AT imammustaphaumar nutrigenomiceffectsofediblebirdsnestoninsulinsignalinginovariectomizedrats
AT ismailmaznah nutrigenomiceffectsofediblebirdsnestoninsulinsignalinginovariectomizedrats
AT ooiderjiun nutrigenomiceffectsofediblebirdsnestoninsulinsignalinginovariectomizedrats
AT iderisaini nutrigenomiceffectsofediblebirdsnestoninsulinsignalinginovariectomizedrats
AT mahmudrozi nutrigenomiceffectsofediblebirdsnestoninsulinsignalinginovariectomizedrats