Pharmacologic therapy for inflammatory bowel disease refractory to steroids

Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, a...

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Detalles Bibliográficos
Autores principales: Martínez-Montiel, MP, Casis-Herce, B, Gómez-Gómez, GJ, Masedo-González, A, Yela-San Bernardino, C, Piedracoba, C, Castellano-Tortajada, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544729/
https://www.ncbi.nlm.nih.gov/pubmed/26316792
http://dx.doi.org/10.2147/CEG.S58152
Descripción
Sumario:Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, and Cochrane reviews on the management of IBD refractory to corticosteroids. Based on this evidence, we propose algorithms and optimization strategies for use of immunomodulator and biologic therapy in IBD refractory to corticosteroids.

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