Pharmacologic therapy for inflammatory bowel disease refractory to steroids

Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, a...

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Autores principales: Martínez-Montiel, MP, Casis-Herce, B, Gómez-Gómez, GJ, Masedo-González, A, Yela-San Bernardino, C, Piedracoba, C, Castellano-Tortajada, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544729/
https://www.ncbi.nlm.nih.gov/pubmed/26316792
http://dx.doi.org/10.2147/CEG.S58152
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author Martínez-Montiel, MP
Casis-Herce, B
Gómez-Gómez, GJ
Masedo-González, A
Yela-San Bernardino, C
Piedracoba, C
Castellano-Tortajada, G
author_facet Martínez-Montiel, MP
Casis-Herce, B
Gómez-Gómez, GJ
Masedo-González, A
Yela-San Bernardino, C
Piedracoba, C
Castellano-Tortajada, G
author_sort Martínez-Montiel, MP
collection PubMed
description Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, and Cochrane reviews on the management of IBD refractory to corticosteroids. Based on this evidence, we propose algorithms and optimization strategies for use of immunomodulator and biologic therapy in IBD refractory to corticosteroids.
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spelling pubmed-45447292015-08-27 Pharmacologic therapy for inflammatory bowel disease refractory to steroids Martínez-Montiel, MP Casis-Herce, B Gómez-Gómez, GJ Masedo-González, A Yela-San Bernardino, C Piedracoba, C Castellano-Tortajada, G Clin Exp Gastroenterol Review Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, and Cochrane reviews on the management of IBD refractory to corticosteroids. Based on this evidence, we propose algorithms and optimization strategies for use of immunomodulator and biologic therapy in IBD refractory to corticosteroids. Dove Medical Press 2015-08-17 /pmc/articles/PMC4544729/ /pubmed/26316792 http://dx.doi.org/10.2147/CEG.S58152 Text en © 2015 Martínez-Montiel et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Martínez-Montiel, MP
Casis-Herce, B
Gómez-Gómez, GJ
Masedo-González, A
Yela-San Bernardino, C
Piedracoba, C
Castellano-Tortajada, G
Pharmacologic therapy for inflammatory bowel disease refractory to steroids
title Pharmacologic therapy for inflammatory bowel disease refractory to steroids
title_full Pharmacologic therapy for inflammatory bowel disease refractory to steroids
title_fullStr Pharmacologic therapy for inflammatory bowel disease refractory to steroids
title_full_unstemmed Pharmacologic therapy for inflammatory bowel disease refractory to steroids
title_short Pharmacologic therapy for inflammatory bowel disease refractory to steroids
title_sort pharmacologic therapy for inflammatory bowel disease refractory to steroids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544729/
https://www.ncbi.nlm.nih.gov/pubmed/26316792
http://dx.doi.org/10.2147/CEG.S58152
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