Cargando…
Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma
BACKGROUND: The aim of this study was to examine possible differences in clinical outcomes between selective laser trabeculoplasty (SLT) and topical medication in the treatment of open-angle glaucoma. METHODS: Pertinent prospective comparative controlled trials comparing SLT with medication were sel...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544808/ https://www.ncbi.nlm.nih.gov/pubmed/26286384 http://dx.doi.org/10.1186/s12886-015-0091-2 |
_version_ | 1782386715294433280 |
---|---|
author | Li, Xingyi Wang, Wei Zhang, Xiulan |
author_facet | Li, Xingyi Wang, Wei Zhang, Xiulan |
author_sort | Li, Xingyi |
collection | PubMed |
description | BACKGROUND: The aim of this study was to examine possible differences in clinical outcomes between selective laser trabeculoplasty (SLT) and topical medication in the treatment of open-angle glaucoma. METHODS: Pertinent prospective comparative controlled trials comparing SLT with medication were selected through extensive searches of the PubMed, Embase, Web of Science, Chinese Biomedicine Database, and the Cochrane Controlled Trials Register database from their inception up to March 2014. Efficacy estimates were measured by their weighted mean difference (WMD) to calculate the intraocular pressure reduction (IOPR) from baseline to endpoint and by the odds ratio (OR) to determine success rates. RESULTS: Five prospective studies, which met the predefined criteria, were included in the meta-analysis. Four studies were randomized clinical trials and one study was a prospective non-randomized clinical trial. There were a total of 492 eyes of 366 patients with open-angle glaucoma. Four studies involving 325 eyes compared SLT with medication in terms of the IOPR. The WMD of the IOPR from the baseline was 0.6 (95 % confidence intervals: −0.24,1.43) when comparing SLT with medication. No statistical heterogeneity was observed between studies (χ2 = 1.30, P = 0.75, I(2) = 0.0 %). All five studies reported success rates, with a pooled OR of 0.84 (95 % confidence intervals: 0.42, 1.68), which was not statistically significant. No statistical heterogeneity was observed between studies (χ2 = 5.98, P = 0.200, I(2) = 33.1 %). Subgroup and sensitivity analysis confirmed the high stability of the meta-analysis results. CONCLUSIONS: Both SLT and topical medication demonstrate similar success rates and effectiveness in lowering intraocular pressure in patients with open-angle glaucoma. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12886-015-0091-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4544808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45448082015-08-22 Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma Li, Xingyi Wang, Wei Zhang, Xiulan BMC Ophthalmol Research Article BACKGROUND: The aim of this study was to examine possible differences in clinical outcomes between selective laser trabeculoplasty (SLT) and topical medication in the treatment of open-angle glaucoma. METHODS: Pertinent prospective comparative controlled trials comparing SLT with medication were selected through extensive searches of the PubMed, Embase, Web of Science, Chinese Biomedicine Database, and the Cochrane Controlled Trials Register database from their inception up to March 2014. Efficacy estimates were measured by their weighted mean difference (WMD) to calculate the intraocular pressure reduction (IOPR) from baseline to endpoint and by the odds ratio (OR) to determine success rates. RESULTS: Five prospective studies, which met the predefined criteria, were included in the meta-analysis. Four studies were randomized clinical trials and one study was a prospective non-randomized clinical trial. There were a total of 492 eyes of 366 patients with open-angle glaucoma. Four studies involving 325 eyes compared SLT with medication in terms of the IOPR. The WMD of the IOPR from the baseline was 0.6 (95 % confidence intervals: −0.24,1.43) when comparing SLT with medication. No statistical heterogeneity was observed between studies (χ2 = 1.30, P = 0.75, I(2) = 0.0 %). All five studies reported success rates, with a pooled OR of 0.84 (95 % confidence intervals: 0.42, 1.68), which was not statistically significant. No statistical heterogeneity was observed between studies (χ2 = 5.98, P = 0.200, I(2) = 33.1 %). Subgroup and sensitivity analysis confirmed the high stability of the meta-analysis results. CONCLUSIONS: Both SLT and topical medication demonstrate similar success rates and effectiveness in lowering intraocular pressure in patients with open-angle glaucoma. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12886-015-0091-2) contains supplementary material, which is available to authorized users. BioMed Central 2015-08-19 /pmc/articles/PMC4544808/ /pubmed/26286384 http://dx.doi.org/10.1186/s12886-015-0091-2 Text en © Li et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Li, Xingyi Wang, Wei Zhang, Xiulan Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma |
title | Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma |
title_full | Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma |
title_fullStr | Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma |
title_full_unstemmed | Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma |
title_short | Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma |
title_sort | meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544808/ https://www.ncbi.nlm.nih.gov/pubmed/26286384 http://dx.doi.org/10.1186/s12886-015-0091-2 |
work_keys_str_mv | AT lixingyi metaanalysisofselectivelasertrabeculoplastyversustopicalmedicationinthetreatmentofopenangleglaucoma AT wangwei metaanalysisofselectivelasertrabeculoplastyversustopicalmedicationinthetreatmentofopenangleglaucoma AT zhangxiulan metaanalysisofselectivelasertrabeculoplastyversustopicalmedicationinthetreatmentofopenangleglaucoma |