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Infant Auditory Processing and Event-related Brain Oscillations

Rapid auditory processing and acoustic change detection abilities play a critical role in allowing human infants to efficiently process the fine spectral and temporal changes that are characteristic of human language. These abilities lay the foundation for effective language acquisition; allowing in...

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Autores principales: Musacchia, Gabriella, Ortiz-Mantilla, Silvia, Realpe-Bonilla, Teresa, Roesler, Cynthia P., Benasich, April A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544907/
https://www.ncbi.nlm.nih.gov/pubmed/26167670
http://dx.doi.org/10.3791/52420
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author Musacchia, Gabriella
Ortiz-Mantilla, Silvia
Realpe-Bonilla, Teresa
Roesler, Cynthia P.
Benasich, April A.
author_facet Musacchia, Gabriella
Ortiz-Mantilla, Silvia
Realpe-Bonilla, Teresa
Roesler, Cynthia P.
Benasich, April A.
author_sort Musacchia, Gabriella
collection PubMed
description Rapid auditory processing and acoustic change detection abilities play a critical role in allowing human infants to efficiently process the fine spectral and temporal changes that are characteristic of human language. These abilities lay the foundation for effective language acquisition; allowing infants to hone in on the sounds of their native language. Invasive procedures in animals and scalp-recorded potentials from human adults suggest that simultaneous, rhythmic activity (oscillations) between and within brain regions are fundamental to sensory development; determining the resolution with which incoming stimuli are parsed. At this time, little is known about oscillatory dynamics in human infant development. However, animal neurophysiology and adult EEG data provide the basis for a strong hypothesis that rapid auditory processing in infants is mediated by oscillatory synchrony in discrete frequency bands. In order to investigate this, 128-channel, high-density EEG responses of 4-month old infants to frequency change in tone pairs, presented in two rate conditions (Rapid: 70 msec ISI and Control: 300 msec ISI) were examined. To determine the frequency band and magnitude of activity, auditory evoked response averages were first co-registered with age-appropriate brain templates. Next, the principal components of the response were identified and localized using a two-dipole model of brain activity. Single-trial analysis of oscillatory power showed a robust index of frequency change processing in bursts of Theta band (3 - 8 Hz) activity in both right and left auditory cortices, with left activation more prominent in the Rapid condition. These methods have produced data that are not only some of the first reported evoked oscillations analyses in infants, but are also, importantly, the product of a well-established method of recording and analyzing clean, meticulously collected, infant EEG and ERPs. In this article, we describe our method for infant EEG net application, recording, dynamic brain response analysis, and representative results.
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spelling pubmed-45449072015-09-03 Infant Auditory Processing and Event-related Brain Oscillations Musacchia, Gabriella Ortiz-Mantilla, Silvia Realpe-Bonilla, Teresa Roesler, Cynthia P. Benasich, April A. J Vis Exp Behavior Rapid auditory processing and acoustic change detection abilities play a critical role in allowing human infants to efficiently process the fine spectral and temporal changes that are characteristic of human language. These abilities lay the foundation for effective language acquisition; allowing infants to hone in on the sounds of their native language. Invasive procedures in animals and scalp-recorded potentials from human adults suggest that simultaneous, rhythmic activity (oscillations) between and within brain regions are fundamental to sensory development; determining the resolution with which incoming stimuli are parsed. At this time, little is known about oscillatory dynamics in human infant development. However, animal neurophysiology and adult EEG data provide the basis for a strong hypothesis that rapid auditory processing in infants is mediated by oscillatory synchrony in discrete frequency bands. In order to investigate this, 128-channel, high-density EEG responses of 4-month old infants to frequency change in tone pairs, presented in two rate conditions (Rapid: 70 msec ISI and Control: 300 msec ISI) were examined. To determine the frequency band and magnitude of activity, auditory evoked response averages were first co-registered with age-appropriate brain templates. Next, the principal components of the response were identified and localized using a two-dipole model of brain activity. Single-trial analysis of oscillatory power showed a robust index of frequency change processing in bursts of Theta band (3 - 8 Hz) activity in both right and left auditory cortices, with left activation more prominent in the Rapid condition. These methods have produced data that are not only some of the first reported evoked oscillations analyses in infants, but are also, importantly, the product of a well-established method of recording and analyzing clean, meticulously collected, infant EEG and ERPs. In this article, we describe our method for infant EEG net application, recording, dynamic brain response analysis, and representative results. MyJove Corporation 2015-07-01 /pmc/articles/PMC4544907/ /pubmed/26167670 http://dx.doi.org/10.3791/52420 Text en Copyright © 2015, Journal of Visualized Experiments http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visithttp://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Behavior
Musacchia, Gabriella
Ortiz-Mantilla, Silvia
Realpe-Bonilla, Teresa
Roesler, Cynthia P.
Benasich, April A.
Infant Auditory Processing and Event-related Brain Oscillations
title Infant Auditory Processing and Event-related Brain Oscillations
title_full Infant Auditory Processing and Event-related Brain Oscillations
title_fullStr Infant Auditory Processing and Event-related Brain Oscillations
title_full_unstemmed Infant Auditory Processing and Event-related Brain Oscillations
title_short Infant Auditory Processing and Event-related Brain Oscillations
title_sort infant auditory processing and event-related brain oscillations
topic Behavior
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544907/
https://www.ncbi.nlm.nih.gov/pubmed/26167670
http://dx.doi.org/10.3791/52420
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