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Emerging trends and persistent challenges in the management of adult syphilis

There are an estimated 10.6 million incident cases of syphilis worldwide each year. We highlight some persistent challenges and emerging trends in the clinical management of syphilis with a particular focus on therapy, serology, diagnostics, and prevention. Decades after the introduction of penicill...

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Detalles Bibliográficos
Autores principales: Tuddenham, Susan, Ghanem, Khalil G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545322/
https://www.ncbi.nlm.nih.gov/pubmed/26286439
http://dx.doi.org/10.1186/s12879-015-1028-3
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author Tuddenham, Susan
Ghanem, Khalil G.
author_facet Tuddenham, Susan
Ghanem, Khalil G.
author_sort Tuddenham, Susan
collection PubMed
description There are an estimated 10.6 million incident cases of syphilis worldwide each year. We highlight some persistent challenges and emerging trends in the clinical management of syphilis with a particular focus on therapy, serology, diagnostics, and prevention. Decades after the introduction of penicillin, the optimal management of early syphilis continues to be a controversial topic, particularly in the setting of HIV co-infection. Similarly, the need for routine lumbar puncture in HIV co-infected asymptomatic persons is an unanswered question. Despite advances in both automation and point-of-care diagnostics, we continue to rely on indirect measures of disease activity to manage this infection. As syphilis rates in some populations continue to rise, novel and effective prevention strategies are needed.
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spelling pubmed-45453222015-08-23 Emerging trends and persistent challenges in the management of adult syphilis Tuddenham, Susan Ghanem, Khalil G. BMC Infect Dis Review There are an estimated 10.6 million incident cases of syphilis worldwide each year. We highlight some persistent challenges and emerging trends in the clinical management of syphilis with a particular focus on therapy, serology, diagnostics, and prevention. Decades after the introduction of penicillin, the optimal management of early syphilis continues to be a controversial topic, particularly in the setting of HIV co-infection. Similarly, the need for routine lumbar puncture in HIV co-infected asymptomatic persons is an unanswered question. Despite advances in both automation and point-of-care diagnostics, we continue to rely on indirect measures of disease activity to manage this infection. As syphilis rates in some populations continue to rise, novel and effective prevention strategies are needed. BioMed Central 2015-08-19 /pmc/articles/PMC4545322/ /pubmed/26286439 http://dx.doi.org/10.1186/s12879-015-1028-3 Text en © Tuddenham and Ghanem. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Tuddenham, Susan
Ghanem, Khalil G.
Emerging trends and persistent challenges in the management of adult syphilis
title Emerging trends and persistent challenges in the management of adult syphilis
title_full Emerging trends and persistent challenges in the management of adult syphilis
title_fullStr Emerging trends and persistent challenges in the management of adult syphilis
title_full_unstemmed Emerging trends and persistent challenges in the management of adult syphilis
title_short Emerging trends and persistent challenges in the management of adult syphilis
title_sort emerging trends and persistent challenges in the management of adult syphilis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545322/
https://www.ncbi.nlm.nih.gov/pubmed/26286439
http://dx.doi.org/10.1186/s12879-015-1028-3
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