Furin-dependent CCL17-fused recombinant toxin controls HTLV-1 infection by targeting and eliminating infected CCR4-expressing cells in vitro and in vivo

BACKGROUND: Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) infection. However, there are no therapies to prevent ATL development in high-risk asymptomatic carriers. To develop a therapy targeting HTLV-1-infected cells that are known to express CCR4 frequently, w...

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Detalles Bibliográficos
Autores principales: Hiyoshi, Masateru, Okuma, Kazu, Tateyama, Seiji, Takizawa, Kazuya, Saito, Masumichi, Kuramitsu, Madoka, Araki, Kumiko, Morishita, Kazuhiro, Okada, Seiji, Yamamoto, Naoki, Biragyn, Arya, Yamaguchi, Kazunari, Hamaguchi, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545545/
https://www.ncbi.nlm.nih.gov/pubmed/26289727
http://dx.doi.org/10.1186/s12977-015-0199-8

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