Organocatalytic Removal of Formaldehyde Adducts from RNA and DNA Bases

Formaldehyde is universally employed to fix tissue specimens, where it forms hemiaminal and aminal adducts with biomolecules, hindering the ability to retrieve molecular information. Common methods for removing these adducts involve extended heating, which can cause extensive degradation of nucleic...

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Detalles Bibliográficos
Autores principales: Karmakar, Saswata, Harcourt, Emily M., Hewings, David S., Lovejoy, Alexander F., Kurtz, David M., Ehrenschwender, Thomas, Barandun, Luzi J., Roost, Caroline, Alizadeh, Ash A., Kool, Eric T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545578/
https://www.ncbi.nlm.nih.gov/pubmed/26291948
http://dx.doi.org/10.1038/nchem.2307

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