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In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation

BACKGROUND: Inflammatory cytokines such as interleukin-1 beta (IL-1β) contribute to the progression of intervertebral disc degeneration. Previously we demonstrated, in vitro, that by delivering interleukin-1 receptor antagonist (IL-1ra) from poly(lactic co-glycolic acid) (PLGA) microspheres, we coul...

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Detalles Bibliográficos
Autores principales:	Gorth, Deborah J, Martin, John T, Dodge, George R, Elliott, Dawn M, Malhotra, Neil R, Mauck, Robert L, Smith, Lachlan J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2014
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545798/ https://www.ncbi.nlm.nih.gov/pubmed/26914760 http://dx.doi.org/10.1186/s40634-014-0015-8

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