CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder

Gallbladder cancer is the most common biliary tract malignancy with the worst overall prognosis. CD109 is a co-receptor of TGF-β1 and suppresses TGF-β signaling. In this study, CD109 protein expression in three subtypes of gallbladder cancer was examined by immunohistochemistry on human tissue sampl...

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Detalles Bibliográficos
Autores principales: Dong, Fengyun, Lu, Chuanfeng, Chen, Xiaocui, Guo, Yuan, Liu, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545819/
https://www.ncbi.nlm.nih.gov/pubmed/26249215
http://dx.doi.org/10.1186/s13000-015-0375-0
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author Dong, Fengyun
Lu, Chuanfeng
Chen, Xiaocui
Guo, Yuan
Liu, Ju
author_facet Dong, Fengyun
Lu, Chuanfeng
Chen, Xiaocui
Guo, Yuan
Liu, Ju
author_sort Dong, Fengyun
collection PubMed
description Gallbladder cancer is the most common biliary tract malignancy with the worst overall prognosis. CD109 is a co-receptor of TGF-β1 and suppresses TGF-β signaling. In this study, CD109 protein expression in three subtypes of gallbladder cancer was examined by immunohistochemistry on human tissue samples and tissue microarrays. We found that CD109 is specifically expressed in malignant squamous cells in squamous cell carcinomas (86.7 %) and adenosquamous carcinomas (91.7 %), but not in adenocarcinomas or normal gallbladder tissues. Thus, CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas.
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spelling pubmed-45458192015-08-23 CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder Dong, Fengyun Lu, Chuanfeng Chen, Xiaocui Guo, Yuan Liu, Ju Diagn Pathol Letter to the Editor Gallbladder cancer is the most common biliary tract malignancy with the worst overall prognosis. CD109 is a co-receptor of TGF-β1 and suppresses TGF-β signaling. In this study, CD109 protein expression in three subtypes of gallbladder cancer was examined by immunohistochemistry on human tissue samples and tissue microarrays. We found that CD109 is specifically expressed in malignant squamous cells in squamous cell carcinomas (86.7 %) and adenosquamous carcinomas (91.7 %), but not in adenocarcinomas or normal gallbladder tissues. Thus, CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas. BioMed Central 2015-08-07 /pmc/articles/PMC4545819/ /pubmed/26249215 http://dx.doi.org/10.1186/s13000-015-0375-0 Text en © Dong et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Dong, Fengyun
Lu, Chuanfeng
Chen, Xiaocui
Guo, Yuan
Liu, Ju
CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder
title CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder
title_full CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder
title_fullStr CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder
title_full_unstemmed CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder
title_short CD109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder
title_sort cd109 is a novel marker for squamous cell/adenosquamous carcinomas of the gallbladder
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545819/
https://www.ncbi.nlm.nih.gov/pubmed/26249215
http://dx.doi.org/10.1186/s13000-015-0375-0
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