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CD146 as an adverse prognostic factor in uterine sarcoma
BACKGROUND: Uterine sarcoma is an aggressive malignancy with a poor prognosis. This study aimed to determine the expression of CD146, P53, and Ki-67 in uterine sarcoma and to evaluate their prognostic significance. METHODS: We retrospectively analyzed the prognosis and clinicopathologic features of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546164/ https://www.ncbi.nlm.nih.gov/pubmed/26293576 http://dx.doi.org/10.1186/s40001-015-0160-2 |
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author | Zhou, Yun Huang, He Yuan, Lin-Jing Xiong, Ying Huang, Xin Lin, Jia-Xin Zheng, Min |
author_facet | Zhou, Yun Huang, He Yuan, Lin-Jing Xiong, Ying Huang, Xin Lin, Jia-Xin Zheng, Min |
author_sort | Zhou, Yun |
collection | PubMed |
description | BACKGROUND: Uterine sarcoma is an aggressive malignancy with a poor prognosis. This study aimed to determine the expression of CD146, P53, and Ki-67 in uterine sarcoma and to evaluate their prognostic significance. METHODS: We retrospectively analyzed the prognosis and clinicopathologic features of 68 patients with uterine sarcoma. Immunohistochemical analyses of CD146, P53, and Ki-67 were performed in tissue samples collected from these patients and their relationship with prognosis was investigated. RESULTS: The 5-year overall survival (OS) rate was 46 %. Endometrial stromal sarcoma (ESS) patients had a better prognosis than leiomyosarcoma (LMS) patients, with a 2-year survival rate of 82 %. The membrane and cytoplasm of tumor cells exhibited CD146 overexpression in 8 (32 %) ESS cases, which was less than the 25 (69.4 %) cases observed in LMS and 2 (28.6 %) in MMMT. CD146 overexpression in the membrane and cytoplasm of tumor cells was closely related to lymph node metastasis (P = 0.021) and Ki-67 overexpression (P = 0.0053); there was no significant correlation with age, tumor size, International Federation of Obstetrics and Gynecology stage, or P53 overexpression in LMS. CONCLUSIONS: CD146, P53, and Ki-67 are overexpressed in uterine sarcoma. CD146 expression correlates with lymph node metastasis and is associated with poor OS in LMS; it may be a potential prognostic marker for LMS. |
format | Online Article Text |
id | pubmed-4546164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45461642015-08-23 CD146 as an adverse prognostic factor in uterine sarcoma Zhou, Yun Huang, He Yuan, Lin-Jing Xiong, Ying Huang, Xin Lin, Jia-Xin Zheng, Min Eur J Med Res Research BACKGROUND: Uterine sarcoma is an aggressive malignancy with a poor prognosis. This study aimed to determine the expression of CD146, P53, and Ki-67 in uterine sarcoma and to evaluate their prognostic significance. METHODS: We retrospectively analyzed the prognosis and clinicopathologic features of 68 patients with uterine sarcoma. Immunohistochemical analyses of CD146, P53, and Ki-67 were performed in tissue samples collected from these patients and their relationship with prognosis was investigated. RESULTS: The 5-year overall survival (OS) rate was 46 %. Endometrial stromal sarcoma (ESS) patients had a better prognosis than leiomyosarcoma (LMS) patients, with a 2-year survival rate of 82 %. The membrane and cytoplasm of tumor cells exhibited CD146 overexpression in 8 (32 %) ESS cases, which was less than the 25 (69.4 %) cases observed in LMS and 2 (28.6 %) in MMMT. CD146 overexpression in the membrane and cytoplasm of tumor cells was closely related to lymph node metastasis (P = 0.021) and Ki-67 overexpression (P = 0.0053); there was no significant correlation with age, tumor size, International Federation of Obstetrics and Gynecology stage, or P53 overexpression in LMS. CONCLUSIONS: CD146, P53, and Ki-67 are overexpressed in uterine sarcoma. CD146 expression correlates with lymph node metastasis and is associated with poor OS in LMS; it may be a potential prognostic marker for LMS. BioMed Central 2015-08-21 /pmc/articles/PMC4546164/ /pubmed/26293576 http://dx.doi.org/10.1186/s40001-015-0160-2 Text en © Zhou et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Zhou, Yun Huang, He Yuan, Lin-Jing Xiong, Ying Huang, Xin Lin, Jia-Xin Zheng, Min CD146 as an adverse prognostic factor in uterine sarcoma |
title | CD146 as an adverse prognostic factor in uterine sarcoma |
title_full | CD146 as an adverse prognostic factor in uterine sarcoma |
title_fullStr | CD146 as an adverse prognostic factor in uterine sarcoma |
title_full_unstemmed | CD146 as an adverse prognostic factor in uterine sarcoma |
title_short | CD146 as an adverse prognostic factor in uterine sarcoma |
title_sort | cd146 as an adverse prognostic factor in uterine sarcoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546164/ https://www.ncbi.nlm.nih.gov/pubmed/26293576 http://dx.doi.org/10.1186/s40001-015-0160-2 |
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