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The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain

BACKGROUND: The γ-secretase complex, composed of transmembrane proteins termed presenilin (PS), anterior pharynx defective (APH), nicastrin (NCT), and presenilin enhancer-2 (Pen-2) catalyzes intramembranous hydrolysis of a variety of Type I membrane protein substrates. In order to understand aspects...

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Detalles Bibliográficos
Autores principales:	Zhang, Xulun, Yu, Chunjiang J., Sisodia, Sangram S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546279/ https://www.ncbi.nlm.nih.gov/pubmed/26296997 http://dx.doi.org/10.1186/s13024-015-0037-4

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