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Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

BACKGROUND: The insulin/IGF1 signalling (IIS) pathways are involved in longevity regulation and are dysregulated in neurons in Alzheimer’s disease (AD). We previously showed downregulation in IIS gene expression in astrocytes with AD-neuropathology progression, but IIS in astrocytes remains poorly u...

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Detalles Bibliográficos
Autores principales:	Garwood, Claire J., Ratcliffe, Laura E., Morgan, Sarah V., Simpson, Julie E., Owens, Helen, Vazquez-Villaseñor, Irina, Heath, Paul R., Romero, Ignacio A., Ince, Paul G., Wharton, Stephen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546315/ https://www.ncbi.nlm.nih.gov/pubmed/26297026 http://dx.doi.org/10.1186/s13041-015-0138-6

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