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Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study

BACKGROUND: Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the metabolism of methionine. Hcy may contribute to the pathogenesis of neurodegenera...

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Autores principales: Zhang, Shuyu, Shi, Changhe, Mao, Chengyuan, Song, Bo, Hou, Haiman, Wu, Jun, Liu, Xinjing, Luo, Haiyang, Sun, Shilei, Xu, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546375/
https://www.ncbi.nlm.nih.gov/pubmed/26291976
http://dx.doi.org/10.1371/journal.pone.0136468
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author Zhang, Shuyu
Shi, Changhe
Mao, Chengyuan
Song, Bo
Hou, Haiman
Wu, Jun
Liu, Xinjing
Luo, Haiyang
Sun, Shilei
Xu, Yuming
author_facet Zhang, Shuyu
Shi, Changhe
Mao, Chengyuan
Song, Bo
Hou, Haiman
Wu, Jun
Liu, Xinjing
Luo, Haiyang
Sun, Shilei
Xu, Yuming
author_sort Zhang, Shuyu
collection PubMed
description BACKGROUND: Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the metabolism of methionine. Hcy may contribute to the pathogenesis of neurodegenerative disorders. Vitamin B12 and folate are cofactors necessary for the methylation of homocysteine. METHODS: This study compared the levels of serum Hcy, vitamin B12 and folate in patients with MSA with those in healthy people to reveal the possible association between MSA and plasma levels of Hcy, vitamin B12 and folate. We enrolled 161 patients with MSA and 161 healthy people in this study. The association between MSA and the levels of Hcy, vitamin B12 and folate were analyzed using binary logistic regression. RESULTS: The mean level of Hcy in patients with MSA was significantly higher than that in healthy controls (16.23 ± 8.09 umol/l vs 14.04 ± 4.25 umol/l, p < 0.05). After adjusting for age, sex and medical history, the odds ratio for Hcy was 1.07 (95% CI = 1.01–1.13, p < 0.05) for patients with MSA. Vitamin B12 and folate levels were not significantly different between patients with MSA and controls. CONCLUSION: Our data suggest that higher levels of Hcy may be associated with an increased risk for MSA.
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spelling pubmed-45463752015-08-26 Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study Zhang, Shuyu Shi, Changhe Mao, Chengyuan Song, Bo Hou, Haiman Wu, Jun Liu, Xinjing Luo, Haiyang Sun, Shilei Xu, Yuming PLoS One Research Article BACKGROUND: Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the metabolism of methionine. Hcy may contribute to the pathogenesis of neurodegenerative disorders. Vitamin B12 and folate are cofactors necessary for the methylation of homocysteine. METHODS: This study compared the levels of serum Hcy, vitamin B12 and folate in patients with MSA with those in healthy people to reveal the possible association between MSA and plasma levels of Hcy, vitamin B12 and folate. We enrolled 161 patients with MSA and 161 healthy people in this study. The association between MSA and the levels of Hcy, vitamin B12 and folate were analyzed using binary logistic regression. RESULTS: The mean level of Hcy in patients with MSA was significantly higher than that in healthy controls (16.23 ± 8.09 umol/l vs 14.04 ± 4.25 umol/l, p < 0.05). After adjusting for age, sex and medical history, the odds ratio for Hcy was 1.07 (95% CI = 1.01–1.13, p < 0.05) for patients with MSA. Vitamin B12 and folate levels were not significantly different between patients with MSA and controls. CONCLUSION: Our data suggest that higher levels of Hcy may be associated with an increased risk for MSA. Public Library of Science 2015-08-20 /pmc/articles/PMC4546375/ /pubmed/26291976 http://dx.doi.org/10.1371/journal.pone.0136468 Text en © 2015 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Shuyu
Shi, Changhe
Mao, Chengyuan
Song, Bo
Hou, Haiman
Wu, Jun
Liu, Xinjing
Luo, Haiyang
Sun, Shilei
Xu, Yuming
Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study
title Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study
title_full Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study
title_fullStr Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study
title_full_unstemmed Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study
title_short Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study
title_sort plasma homocysteine, vitamin b12 and folate levels in multiple system atrophy: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546375/
https://www.ncbi.nlm.nih.gov/pubmed/26291976
http://dx.doi.org/10.1371/journal.pone.0136468
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