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Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling

The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have evolved. These include changes in its active s...

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Detalles Bibliográficos
Autores principales:	Marada, Suresh, Navarro, Gemma, Truong, Ashley, Stewart, Daniel P., Arensdorf, Angela M., Nachtergaele, Sigrid, Angelats, Edgar, Opferman, Joseph T., Rohatgi, Rajat, McCormick, Peter J., Ogden, Stacey K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546403/ https://www.ncbi.nlm.nih.gov/pubmed/26291458 http://dx.doi.org/10.1371/journal.pgen.1005473

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