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Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy
DNA-PK is an enzyme that is required for proper DNA-repair and is thought to confer radio-resistance in cancer cells. As a consequence, it is a high-profile validated target for new pharmaceutical development. However, no FDA-approved DNA-PK inhibitors have emerged, despite many years of drug discov...
Autores principales: | Lamb, Rebecca, Fiorillo, Marco, Chadwick, Amy, Ozsvari, Bela, Reeves, Kimberly J., Smith, Duncan L., Clarke, Robert B., Howell, Sacha J., Cappello, Anna Rita, Martinez-Outschoorn, Ubaldo E., Peiris-Pagès, Maria, Sotgia, Federica, Lisanti, Michael P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546447/ https://www.ncbi.nlm.nih.gov/pubmed/26087309 |
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