miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases

MicroRNAs are involved in the initiation and progression of pancreatic cancer. In this study, we showed that miR-221/222 is overexpressed in pancreatic cancer. MiR-221/222 overexpression significantly promoted pancreatic cancer cell proliferation and invasion while inhibiting apoptosis. The expressi...

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Detalles Bibliográficos
Autores principales: Xu, Qinhong, Li, Pei, Chen, Xin, Zong, Liang, Jiang, Zhengdong, Nan, Ligang, Lei, Jianjun, Duan, Wanxing, Zhang, Dong, Li, Xuqi, Sha, Huanchen, Wu, Zheng, Ma, Qingyong, Wang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546457/
https://www.ncbi.nlm.nih.gov/pubmed/25883224
Descripción
Sumario:MicroRNAs are involved in the initiation and progression of pancreatic cancer. In this study, we showed that miR-221/222 is overexpressed in pancreatic cancer. MiR-221/222 overexpression significantly promoted pancreatic cancer cell proliferation and invasion while inhibiting apoptosis. The expression of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9 was increased in miR-221/222 mimic-transfected pancreatic cancer cells. Validation experiments identified TIMP-2 as a direct target of miR-221/222. These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion.

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