Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment

The POU class 1 homeobox 1 (POU1F1, also known as Pit-1), pertaining to the Pit-Oct-Unc (POU) family of transcription factors, has been related to tumor growth and metastasis in breast. However, its role in response to breast cancer therapy is unknown. We found that Pit-1 down-regulated DNA-damage a...

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Detalles Bibliográficos
Autores principales: Seoane, Samuel, Arias, Efigenia, Sigueiro, Rita, Sendon-Lago, Juan, Martinez-Ordoñez, Anxo, Castelao, Esteban, Eiró, Noemí, Garcia-Caballero, Tomás, Macia, Manuel, Lopez-Lopez, Rafael, Maestro, Miguel, Vizoso, Francisco, Mouriño, Antonio, Perez-Fernandez, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546479/
https://www.ncbi.nlm.nih.gov/pubmed/25992773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546479/
https://www.ncbi.nlm.nih.gov/pubmed/25992773

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