Cargando…

Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment

The POU class 1 homeobox 1 (POU1F1, also known as Pit-1), pertaining to the Pit-Oct-Unc (POU) family of transcription factors, has been related to tumor growth and metastasis in breast. However, its role in response to breast cancer therapy is unknown. We found that Pit-1 down-regulated DNA-damage a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seoane, Samuel, Arias, Efigenia, Sigueiro, Rita, Sendon-Lago, Juan, Martinez-Ordoñez, Anxo, Castelao, Esteban, Eiró, Noemí, Garcia-Caballero, Tomás, Macia, Manuel, Lopez-Lopez, Rafael, Maestro, Miguel, Vizoso, Francisco, Mouriño, Antonio, Perez-Fernandez, Roman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546479/ https://www.ncbi.nlm.nih.gov/pubmed/25992773

Ejemplares similares

Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13
por: Sendon-Lago, Juan, et al.
Publicado: (2014)

Erratum to: Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13
por: Sendon-Lago, Juan, et al.
Publicado: (2017)

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation
por: Martínez-Ordoñez, Anxo, et al.
Publicado: (2021)

26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D(3) (1,25D-d(6)) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines
por: Seoane, Samuel, et al.
Publicado: (2013)

The Pit-1/Pou1f1 transcription factor regulates and correlates with prolactin expression in human breast cell lines and tumors
por: Ben-Batalla, I, et al.
Publicado: (2010)

Potential therapeutic effect of the secretome from human uterine cervical stem cells against both cancer and stromal cells compared with adipose tissue stem cells
por: Eiró, Noemí, et al.
Publicado: (2014)

Carborane-based design of a potent vitamin D receptor agonist
por: Otero, Rocio, et al.
Publicado: (2016)

Tailored Hydrogels as Delivery Platforms for Conditioned Medium from Mesenchymal Stem Cells in a Model of Acute Colitis in Mice
por: Sendon-Lago, Juan, et al.
Publicado: (2021)

Mesenchymal Stem/Stromal Cells and Their Derivates in Acute Diseases: Emergency in the Post-COVID-19 Times
por: Vizoso, Francisco J., et al.
Publicado: (2021)

Cisplatin in breast cancer treatment in BRCA1 carriers
por: Gronwald, Jacek, et al.
Publicado: (2012)

Towards a New Concept of Regenerative Endodontics Based on Mesenchymal Stem Cell-Derived Secretomes Products
por: Costa, Luis A., et al.
Publicado: (2022)

Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis
por: Eiró, Noemi, et al.
Publicado: (2013)

Mesenchymal Stem Cell-Based Therapy as an Alternative to the Treatment of Acute Respiratory Distress Syndrome: Current Evidence and Future Perspectives
por: Fernández-Francos, Silvia, et al.
Publicado: (2021)

Antifungal Activity of the Human Uterine Cervical Stem Cells Conditioned Medium (hUCESC-CM) Against Candida albicans and Other Medically Relevant Species of Candida
por: Schneider, José, et al.
Publicado: (2018)

Corrigendum: Antifungal Activity of the Human Uterine Cervical Stem Cells Conditioned Medium (hUCESC-CM) Against Candida albicans and Other Medically Relevant Species of Candida
por: Schneider, José, et al.
Publicado: (2019)

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine
por: Vizoso, Francisco J., et al.
Publicado: (2017)

The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells
por: Eiro, Noemi, et al.
Publicado: (2020)

Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies
por: Fraile, Maria, et al.
Publicado: (2022)

Why choose the treatment with cisplatin for BRCA1 breast cancers patients?
por: Byrski, T, et al.
Publicado: (2012)

Neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
por: Byrski, T, et al.
Publicado: (2011)

Neoadjuvant chemotherapy with Cisplatin in BRCA1 mutation carriers – results of treatment
por: Byrski, T, et al.
Publicado: (2012)

Mesenchymal (Stem) Stromal Cells Based as New Therapeutic Alternative in Inflammatory Bowel Disease: Basic Mechanisms, Experimental and Clinical Evidence, and Challenges
por: Eiro, Noemi, et al.
Publicado: (2022)

1α,25(OH)(2)-3-Epi-Vitamin D(3), a Natural Physiological Metabolite of Vitamin D(3): Its Synthesis, Biological Activity and Crystal Structure with Its Receptor
por: Molnár, Ferdinand, et al.
Publicado: (2011)

BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to PARP Inhibitors and Cisplatin
por: Endo, Shino, et al.
Publicado: (2021)

Breast Cancer Tumor Stroma: Cellular Components, Phenotypic Heterogeneity, Intercellular Communication, Prognostic Implications and Therapeutic Opportunities
por: Eiro, Noemi, et al.
Publicado: (2019)

PITS: An Intelligent Transportation System in pandemic times
por: Brazález, Enrique, et al.
Publicado: (2022)

In Silico Identification of a BRCA1:miR-29:DNMT3 Axis Involved in the Control of Hormone Receptors in BRCA1-Associated Breast Cancers
por: Santarosa, Manuela, et al.
Publicado: (2023)

MMP1 and MMP11 Expression in Peripheral Blood Mononuclear Cells upon Their Interaction with Breast Cancer Cells and Fibroblasts
por: Eiro, Noemi, et al.
Publicado: (2020)

Analysis of the Gene Expression Profile of Stromal Pro-Tumor Factors in Cancer-Associated Fibroblasts from Luminal Breast Carcinomas
por: Eiro, Noemi, et al.
Publicado: (2020)

Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: “alliance” or “war” in intercellular signals
por: Eiro, Noemi, et al.
Publicado: (2021)

Relationship between Metalloprotease-7 and -14 and Tissue Inhibitor of Metalloprotease 1 Expression by Mucosal Stromal Cells and Colorectal Cancer Development in Inflammatory Bowel Disease
por: Altadill, Antonio, et al.
Publicado: (2021)

Ixr1 Regulates Ribosomal Gene Transcription and Yeast Response to Cisplatin
por: Vizoso-Vázquez, Ángel, et al.
Publicado: (2018)

Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells
por: Alli, Elizabeth, et al.
Publicado: (2011)

Pathological complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients
por: Byrski, Tomasz, et al.
Publicado: (2015)

BRCA1 and STMN1 as prognostic markers in NSCLCs who received cisplatin-based adjuvant chemotherapy
por: Wang, Mingxing, et al.
Publicado: (2017)

Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival
por: Chande, Sampada, et al.
Publicado: (2020)

Relationship between Arterial Calcifications on Mammograms and Cardiovascular Events: A Twenty-Three Year Follow-Up Retrospective Cohort Study
por: Galiano, Natalia González, et al.
Publicado: (2022)

In Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein
por: Atipairin, Apichart, et al.
Publicado: (2011)

Neoadjuvant therapy of BRCA1-driven ovarian cancer by combination of cisplatin, mitomycin C and doxorubicin
por: Gorodnova, Tatiana V., et al.
Publicado: (2021)

Sky1 regulates the expression of sulfur metabolism genes in response to cisplatin
por: Rodríguez-Lombardero, Silvia, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jf68n1akosl0bf550sh7a9e6le