Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo

Despite great efforts taken to advance therapeutic measures for patients with glioblastoma, the clinical prognosis remains grim. The antiapoptotic Bcl-2 family protein Mcl-1 is overexpressed in glioblastoma and represents an important resistance factor to the BH-3 mimetic ABT263. In this study, we s...

Descripción completa

Detalles Bibliográficos
Autores principales: Karpel-Massler, Georg, Shu, Chang, Chau, Lily, Banu, Matei, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Ramirez, Yulian, Ross, Alonzo H., Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546483/
https://www.ncbi.nlm.nih.gov/pubmed/26008975

Ejemplares similares

Ejemplares similares