Creation of Mice Bearing a Partial Duplication of HPRT Gene Marked with a GFP Gene and Detection of Revertant Cells In Situ as GFP-Positive Somatic Cells

It is becoming clear that apparently normal somatic cells accumulate mutations. Such accumulations or propagations of mutant cells are thought to be related to certain diseases such as cancer. To better understand the nature of somatic mutations, we developed a mouse model that enables in vivo detec...

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Detalles Bibliográficos
Autores principales: Noda, Asao, Suemori, Hirofumi, Hirai, Yuko, Hamasaki, Kanya, Kodama, Yoshiaki, Mitani, Hiroshi, Landes, Reid D., Nakamura, Nori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546575/
https://www.ncbi.nlm.nih.gov/pubmed/26295470
http://dx.doi.org/10.1371/journal.pone.0136041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546575/
https://www.ncbi.nlm.nih.gov/pubmed/26295470
http://dx.doi.org/10.1371/journal.pone.0136041

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