YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is observed in several types of human cancers. Here we investigated its genomic binding landscape in YAP1-activated cancer cells, a...

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Detalles Bibliográficos
Autores principales: Stein, Claudia, Bardet, Anaïs Flore, Roma, Guglielmo, Bergling, Sebastian, Clay, Ieuan, Ruchti, Alexandra, Agarinis, Claudia, Schmelzle, Tobias, Bouwmeester, Tewis, Schübeler, Dirk, Bauer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546604/
https://www.ncbi.nlm.nih.gov/pubmed/26295846
http://dx.doi.org/10.1371/journal.pgen.1005465

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