The Aspergillus fumigatus pkcA (G579R) Mutant Is Defective in the Activation of the Cell Wall Integrity Pathway but Is Dispensable for Virulence in a Neutropenic Mouse Infection Model

Aspergillus fumigatus is an opportunistic human pathogen, which causes the life-threatening disease, invasive pulmonary aspergillosis. In fungi, cell wall homeostasis is controlled by the conserved Cell Wall Integrity (CWI) pathway. In A. fumigatus this signaling cascade is partially characterized,...

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Detalles Bibliográficos
Autores principales: Rocha, Marina Campos, de Godoy, Krissia Franco, de Castro, Patrícia Alves, Hori, Juliana Issa, Bom, Vinícius Leite Pedro, Brown, Neil Andrew, da Cunha, Anderson Ferreira, Goldman, Gustavo Henrique, Malavazi, Iran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546635/
https://www.ncbi.nlm.nih.gov/pubmed/26295576
http://dx.doi.org/10.1371/journal.pone.0135195

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