Hdh(Q111) Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation

The HTT CAG expansion mutation causes Huntington’s Disease and is associated with a wide range of cellular consequences, including altered metabolism. The mutant allele is expressed widely, in all tissues, but the striatum and cortex are especially vulnerable to its effects. To more fully understand...

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Detalles Bibliográficos
Autores principales: Carroll, Jeffrey B., Deik, Amy, Fossale, Elisa, Weston, Rory M., Guide, Jolene R., Arjomand, Jamshid, Kwak, Seung, Clish, Clary B., MacDonald, Marcy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546654/
https://www.ncbi.nlm.nih.gov/pubmed/26295712
http://dx.doi.org/10.1371/journal.pone.0134465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546654/
https://www.ncbi.nlm.nih.gov/pubmed/26295712
http://dx.doi.org/10.1371/journal.pone.0134465

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