Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain

Cav1.3 L-type Ca(2+)-channel function is regulated by a C-terminal automodulatory domain (CTM). It affects channel binding of calmodulin and thereby tunes channel activity by interfering with Ca(2+)- and voltage-dependent gating. Alternative splicing generates short C-terminal channel variants lacki...

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Detalles Bibliográficos
Autores principales: Scharinger, Anja, Eckrich, Stephanie, Vandael, David H., Schönig, Kai, Koschak, Alexandra, Hecker, Dietmar, Kaur, Gurjot, Lee, Amy, Sah, Anupam, Bartsch, Dusan, Benedetti, Bruno, Lieb, Andreas, Schick, Bernhard, Singewald, Nicolas, Sinnegger-Brauns, Martina J., Carbone, Emilio, Engel, Jutta, Striessnig, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547004/
https://www.ncbi.nlm.nih.gov/pubmed/26379493
http://dx.doi.org/10.3389/fncel.2015.00309

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