Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

Recent studies have demonstrated that the actin binding protein, ezrin, and the cAMP-sensor, EPAC1, cooperate to induce cell spreading in response to elevations in intracellular cAMP. To investigate the mechanisms underlying these effects we generated a model of EPAC1-dependent cell spreading based...

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Detalles Bibliográficos
Autores principales: Parnell, Euan, Koschinski, Andreas, Zaccolo, Manuela, Cameron, Ryan T., Baillie, George S., Baillie, Gemma L., Porter, Alison, McElroy, Stuart P., Yarwood, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547084/
https://www.ncbi.nlm.nih.gov/pubmed/25913012
http://dx.doi.org/10.1016/j.bbamcr.2015.04.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547084/
https://www.ncbi.nlm.nih.gov/pubmed/25913012
http://dx.doi.org/10.1016/j.bbamcr.2015.04.009

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