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TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

Somatic mutations in the tumour suppressor gene TP53 occur in more than 50% of human tumours; in some instances exposure to environmental carcinogens can be linked to characteristic mutational signatures. The Hupki (human TP53 knock-in) mouse embryo fibroblast (HUF) immortalization assay (HIMA) is a...

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Detalles Bibliográficos
Autores principales:	Kucab, Jill E., van Steeg, Harry, Luijten, Mirjam, Schmeiser, Heinz H., White, Paul A., Phillips, David H., Arlt, Volker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547099/ https://www.ncbi.nlm.nih.gov/pubmed/25847421 http://dx.doi.org/10.1016/j.mrfmmm.2015.01.013

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