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STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3

Interferons (IFNs) potentiate macrophage activation typically via a STAT1-dependent pathway. Recent studies suggest a functioning of STAT1-independent pathway in the regulation of gene expression by IFN-γ, thus pointing to the diversity in cellular responses to IFNs. Many functions of IFNs rely on c...

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Detalles Bibliográficos
Autores principales:	Kim, Hun Sik, Kim, Dong Chan, Kim, Hong-Mi, Kwon, Hyung-Joon, Kwon, Soon Jae, Kang, Suk-Jo, Kim, Sun Chang, Choi, Go-Eun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547106/ https://www.ncbi.nlm.nih.gov/pubmed/26299368 http://dx.doi.org/10.1038/srep13414

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