Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability

Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not satisfactorily respond to the present-day drugs. We found that the natural...

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Detalles Bibliográficos
Autores principales: Ottosson, Nina E, Wu, Xiongyu, Nolting, Andreas, Karlsson, Urban, Lund, Per-Eric, Ruda, Katinka, Svensson, Stefan, Konradsson, Peter, Elinder, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547393/
https://www.ncbi.nlm.nih.gov/pubmed/26299574
http://dx.doi.org/10.1038/srep13278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547393/
https://www.ncbi.nlm.nih.gov/pubmed/26299574
http://dx.doi.org/10.1038/srep13278

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