Cargando…
Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability
Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not satisfactorily respond to the present-day drugs. We found that the natural...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547393/ https://www.ncbi.nlm.nih.gov/pubmed/26299574 http://dx.doi.org/10.1038/srep13278 |