Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results

Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we...

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Detalles Bibliográficos
Autores principales: Hu, Qin, Manaenko, Anatol, Guo, Zhenni, Huang, Lei, Tang, Jiping, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547434/
https://www.ncbi.nlm.nih.gov/pubmed/26306183
http://dx.doi.org/10.1186/s13618-015-0033-3
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author Hu, Qin
Manaenko, Anatol
Guo, Zhenni
Huang, Lei
Tang, Jiping
Zhang, John H.
author_facet Hu, Qin
Manaenko, Anatol
Guo, Zhenni
Huang, Lei
Tang, Jiping
Zhang, John H.
author_sort Hu, Qin
collection PubMed
description Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we reviewed the clinical studies of HBOT in PCS, summarized the limitations of these studies, and discussed the limitations: inappropriate Sham group using room air at 1.2 or 1.3 ATA; delayed HBO administration; subjective assessment methods; time point for outcome assessment and small sample size. We hope that our concerns will be helpful for future clinical studies of HBO therapy in TBI or other neurological disorders.
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spelling pubmed-45474342015-08-25 Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results Hu, Qin Manaenko, Anatol Guo, Zhenni Huang, Lei Tang, Jiping Zhang, John H. Med Gas Res Commentary Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we reviewed the clinical studies of HBOT in PCS, summarized the limitations of these studies, and discussed the limitations: inappropriate Sham group using room air at 1.2 or 1.3 ATA; delayed HBO administration; subjective assessment methods; time point for outcome assessment and small sample size. We hope that our concerns will be helpful for future clinical studies of HBO therapy in TBI or other neurological disorders. BioMed Central 2015-08-25 /pmc/articles/PMC4547434/ /pubmed/26306183 http://dx.doi.org/10.1186/s13618-015-0033-3 Text en © Hu et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Hu, Qin
Manaenko, Anatol
Guo, Zhenni
Huang, Lei
Tang, Jiping
Zhang, John H.
Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
title Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
title_full Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
title_fullStr Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
title_full_unstemmed Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
title_short Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
title_sort hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547434/
https://www.ncbi.nlm.nih.gov/pubmed/26306183
http://dx.doi.org/10.1186/s13618-015-0033-3
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