Cargando…

REDD1 Is Essential for Optimal T Cell Proliferation and Survival

REDD1 is a highly conserved stress response protein that is upregulated following many types of cellular stress, including hypoxia, DNA damage, energy stress, ER stress, and nutrient deprivation. Recently, REDD1 was shown to be involved in dexamethasone induced autophagy in murine thymocytes. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales: Reuschel, Emma L., Wang, JiangFang, Shivers, Debra K., Muthumani, Karuppiah, Weiner, David B., Ma, Zhengyu, Finkel, Terri H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547781/
https://www.ncbi.nlm.nih.gov/pubmed/26301899
http://dx.doi.org/10.1371/journal.pone.0136323
_version_ 1782387110348587008
author Reuschel, Emma L.
Wang, JiangFang
Shivers, Debra K.
Muthumani, Karuppiah
Weiner, David B.
Ma, Zhengyu
Finkel, Terri H.
author_facet Reuschel, Emma L.
Wang, JiangFang
Shivers, Debra K.
Muthumani, Karuppiah
Weiner, David B.
Ma, Zhengyu
Finkel, Terri H.
author_sort Reuschel, Emma L.
collection PubMed
description REDD1 is a highly conserved stress response protein that is upregulated following many types of cellular stress, including hypoxia, DNA damage, energy stress, ER stress, and nutrient deprivation. Recently, REDD1 was shown to be involved in dexamethasone induced autophagy in murine thymocytes. However, we know little of REDD1’s function in mature T cells. Here we show for the first time that REDD1 is upregulated following T cell stimulation with PHA or CD3/CD28 beads. REDD1 knockout T cells exhibit a defect in proliferation and cell survival, although markers of activation appear normal. These findings demonstrate a previously unappreciated role for REDD1 in T cell function.
format Online
Article
Text
id pubmed-4547781
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-45477812015-09-01 REDD1 Is Essential for Optimal T Cell Proliferation and Survival Reuschel, Emma L. Wang, JiangFang Shivers, Debra K. Muthumani, Karuppiah Weiner, David B. Ma, Zhengyu Finkel, Terri H. PLoS One Research Article REDD1 is a highly conserved stress response protein that is upregulated following many types of cellular stress, including hypoxia, DNA damage, energy stress, ER stress, and nutrient deprivation. Recently, REDD1 was shown to be involved in dexamethasone induced autophagy in murine thymocytes. However, we know little of REDD1’s function in mature T cells. Here we show for the first time that REDD1 is upregulated following T cell stimulation with PHA or CD3/CD28 beads. REDD1 knockout T cells exhibit a defect in proliferation and cell survival, although markers of activation appear normal. These findings demonstrate a previously unappreciated role for REDD1 in T cell function. Public Library of Science 2015-08-24 /pmc/articles/PMC4547781/ /pubmed/26301899 http://dx.doi.org/10.1371/journal.pone.0136323 Text en © 2015 Reuschel et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Reuschel, Emma L.
Wang, JiangFang
Shivers, Debra K.
Muthumani, Karuppiah
Weiner, David B.
Ma, Zhengyu
Finkel, Terri H.
REDD1 Is Essential for Optimal T Cell Proliferation and Survival
title REDD1 Is Essential for Optimal T Cell Proliferation and Survival
title_full REDD1 Is Essential for Optimal T Cell Proliferation and Survival
title_fullStr REDD1 Is Essential for Optimal T Cell Proliferation and Survival
title_full_unstemmed REDD1 Is Essential for Optimal T Cell Proliferation and Survival
title_short REDD1 Is Essential for Optimal T Cell Proliferation and Survival
title_sort redd1 is essential for optimal t cell proliferation and survival
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547781/
https://www.ncbi.nlm.nih.gov/pubmed/26301899
http://dx.doi.org/10.1371/journal.pone.0136323
work_keys_str_mv AT reuschelemmal redd1isessentialforoptimaltcellproliferationandsurvival
AT wangjiangfang redd1isessentialforoptimaltcellproliferationandsurvival
AT shiversdebrak redd1isessentialforoptimaltcellproliferationandsurvival
AT muthumanikaruppiah redd1isessentialforoptimaltcellproliferationandsurvival
AT weinerdavidb redd1isessentialforoptimaltcellproliferationandsurvival
AT mazhengyu redd1isessentialforoptimaltcellproliferationandsurvival
AT finkelterrih redd1isessentialforoptimaltcellproliferationandsurvival