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Increased Circulating Cathepsin K in Patients with Chronic Heart Failure

Cysteinyl cathepsin K (CatK) is one of the most potent mammalian collagenases involved in cardiovascular disease. Here, we investigated the clinical predictive value of serum CatK levels in patients with chronic heart failure (CHF). We examined 134 patients with CHF, measuring their serum CatK, trop...

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Autores principales: Zhao, Guangxian, Li, Yuzi, Cui, Lan, Li, Xiang, Jin, Zhenyi, Han, Xiongyi, Fang, Ennan, Gao, Yihua, Zhou, Dongmei, Jiang, Haiying, Jin, Xueying, Piao, Guanghao, Li, Xiangshan, Yang, Guang, Jin, Jiyong, Zhu, Enbo, Piao, Meina, Piao, Limei, Yuan, Kuichang, Lei, Yanna, Ding, Dazhi, Jin, Chengzhi, Nan, Yongshan, Cheng, Xianwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547812/
https://www.ncbi.nlm.nih.gov/pubmed/26302400
http://dx.doi.org/10.1371/journal.pone.0136093
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author Zhao, Guangxian
Li, Yuzi
Cui, Lan
Li, Xiang
Jin, Zhenyi
Han, Xiongyi
Fang, Ennan
Gao, Yihua
Zhou, Dongmei
Jiang, Haiying
Jin, Xueying
Piao, Guanghao
Li, Xiangshan
Yang, Guang
Jin, Jiyong
Zhu, Enbo
Piao, Meina
Piao, Limei
Yuan, Kuichang
Lei, Yanna
Ding, Dazhi
Jin, Chengzhi
Nan, Yongshan
Cheng, Xianwu
author_facet Zhao, Guangxian
Li, Yuzi
Cui, Lan
Li, Xiang
Jin, Zhenyi
Han, Xiongyi
Fang, Ennan
Gao, Yihua
Zhou, Dongmei
Jiang, Haiying
Jin, Xueying
Piao, Guanghao
Li, Xiangshan
Yang, Guang
Jin, Jiyong
Zhu, Enbo
Piao, Meina
Piao, Limei
Yuan, Kuichang
Lei, Yanna
Ding, Dazhi
Jin, Chengzhi
Nan, Yongshan
Cheng, Xianwu
author_sort Zhao, Guangxian
collection PubMed
description Cysteinyl cathepsin K (CatK) is one of the most potent mammalian collagenases involved in cardiovascular disease. Here, we investigated the clinical predictive value of serum CatK levels in patients with chronic heart failure (CHF). We examined 134 patients with CHF, measuring their serum CatK, troponin I, high-sensitive C-reactive protein, and pre-operative N-terminal pro-brain natriuretic peptide levels. The patients were divided into two groups: the 44 patients who showed a left ventricular (LV) ejection fraction (LVEF) < 40% (the “lowLVEF” group) and the 90 patients showing LVEF values ≥ 40% (the “highLVEF” group). The lowLVEF patients had significantly higher serum CatK levels compared to the highLVEF patients (58.4 ± 12.2 vs. 44.7 ± 16.4, P < 0.001). Overall, a linear regression analysis showed that CatK levels correlated negatively with LVEF (r = −0.4, P < 0.001) and positively with LV end-diastolic dimensions (r = 0.2, P < 0.01), LV end-systolic dimensions (r = 0.3, P < 0.001), and left atrial diameters (r = 0.3, P < 0.01). A multiple logistic regression analysis showed that CatK levels were independent predictors of CHF (odds ratio, 0.90; 95% confidence interval, 0.84–0.95; P < 0.01). These data indicate that elevated levels of CatK are closely associated with the presence of CHF and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of cardiac remodeling and dysfunction in patients with CHF.
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spelling pubmed-45478122015-09-01 Increased Circulating Cathepsin K in Patients with Chronic Heart Failure Zhao, Guangxian Li, Yuzi Cui, Lan Li, Xiang Jin, Zhenyi Han, Xiongyi Fang, Ennan Gao, Yihua Zhou, Dongmei Jiang, Haiying Jin, Xueying Piao, Guanghao Li, Xiangshan Yang, Guang Jin, Jiyong Zhu, Enbo Piao, Meina Piao, Limei Yuan, Kuichang Lei, Yanna Ding, Dazhi Jin, Chengzhi Nan, Yongshan Cheng, Xianwu PLoS One Research Article Cysteinyl cathepsin K (CatK) is one of the most potent mammalian collagenases involved in cardiovascular disease. Here, we investigated the clinical predictive value of serum CatK levels in patients with chronic heart failure (CHF). We examined 134 patients with CHF, measuring their serum CatK, troponin I, high-sensitive C-reactive protein, and pre-operative N-terminal pro-brain natriuretic peptide levels. The patients were divided into two groups: the 44 patients who showed a left ventricular (LV) ejection fraction (LVEF) < 40% (the “lowLVEF” group) and the 90 patients showing LVEF values ≥ 40% (the “highLVEF” group). The lowLVEF patients had significantly higher serum CatK levels compared to the highLVEF patients (58.4 ± 12.2 vs. 44.7 ± 16.4, P < 0.001). Overall, a linear regression analysis showed that CatK levels correlated negatively with LVEF (r = −0.4, P < 0.001) and positively with LV end-diastolic dimensions (r = 0.2, P < 0.01), LV end-systolic dimensions (r = 0.3, P < 0.001), and left atrial diameters (r = 0.3, P < 0.01). A multiple logistic regression analysis showed that CatK levels were independent predictors of CHF (odds ratio, 0.90; 95% confidence interval, 0.84–0.95; P < 0.01). These data indicate that elevated levels of CatK are closely associated with the presence of CHF and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of cardiac remodeling and dysfunction in patients with CHF. Public Library of Science 2015-08-24 /pmc/articles/PMC4547812/ /pubmed/26302400 http://dx.doi.org/10.1371/journal.pone.0136093 Text en © 2015 Zhao et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhao, Guangxian
Li, Yuzi
Cui, Lan
Li, Xiang
Jin, Zhenyi
Han, Xiongyi
Fang, Ennan
Gao, Yihua
Zhou, Dongmei
Jiang, Haiying
Jin, Xueying
Piao, Guanghao
Li, Xiangshan
Yang, Guang
Jin, Jiyong
Zhu, Enbo
Piao, Meina
Piao, Limei
Yuan, Kuichang
Lei, Yanna
Ding, Dazhi
Jin, Chengzhi
Nan, Yongshan
Cheng, Xianwu
Increased Circulating Cathepsin K in Patients with Chronic Heart Failure
title Increased Circulating Cathepsin K in Patients with Chronic Heart Failure
title_full Increased Circulating Cathepsin K in Patients with Chronic Heart Failure
title_fullStr Increased Circulating Cathepsin K in Patients with Chronic Heart Failure
title_full_unstemmed Increased Circulating Cathepsin K in Patients with Chronic Heart Failure
title_short Increased Circulating Cathepsin K in Patients with Chronic Heart Failure
title_sort increased circulating cathepsin k in patients with chronic heart failure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547812/
https://www.ncbi.nlm.nih.gov/pubmed/26302400
http://dx.doi.org/10.1371/journal.pone.0136093
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