Cargando…

Immunologic monitoring during a phase 2a trial of the GNbAC1 antibody in patients with MS

OBJECTIVE: To monitor the systemic immune responses of patients with multiple sclerosis (MS) under treatment with GNbAC1, a monoclonal antibody against the envelope protein of the MS- associated retrovirus, during a phase 2a trial. METHODS: We analyzed the composition of immune cell subsets and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zimmermann, Maria, Sanderson, Nicholas S.R., Rasenack, Maria, Lalive, Patrice H., Lang, Alois B., Curtin, Francois, Lindberg, Raija L.P., Kappos, Ludwig, Derfuss, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547879/ https://www.ncbi.nlm.nih.gov/pubmed/26380353 http://dx.doi.org/10.1212/NXI.0000000000000144

Ejemplares similares

The monoclonal antibody GNbAC1: targeting human endogenous retroviruses in multiple sclerosis
por: Diebold, Martin, et al.
Publicado: (2019)

Natalizumab-induced POU2AF1/Spi-B upregulation: A possible route for PML development
por: Meira, Maria, et al.
Publicado: (2016)

Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4(+) T Cells of Patients with Relapsing-Remitting Multiple Sclerosis
por: Meira, Maria, et al.
Publicado: (2014)

Efficacy and Safety of Fingolimod in an Unselected Patient Population
por: Rasenack, Maria, et al.
Publicado: (2016)

Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype
por: Pröbstel, Anne-Katrin, et al.
Publicado: (2015)

PARP-1 deregulation in multiple sclerosis
por: Meira, Maria, et al.
Publicado: (2019)

Natalizumab in cerebrospinal fluid and breastmilk of patients with multiple sclerosis
por: Callegari, Ilaria, et al.
Publicado: (2023)

Antigen Extraction and B Cell Activation Enable Identification of Rare Membrane Antigen Specific Human B Cells
por: Zimmermann, Maria, et al.
Publicado: (2019)

Gut microbiota composition as a candidate risk factor for dimethyl fumarate-induced lymphopenia in multiple sclerosis
por: Diebold, Martin, et al.
Publicado: (2022)

Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
por: Diebold, Martin, et al.
Publicado: (2022)

Prognostic and Immunological Value of GNB4 in Gastric Cancer by Analyzing TCGA Database
por: Liu, Binghui, et al.
Publicado: (2022)

Hepatitis E virus infections in patients with MS on oral disease-modifying treatment
por: Diebold, Martin, et al.
Publicado: (2019)

Severe exacerbation of relapsing-remitting multiple sclerosis after G-CSF therapy
por: Rust, Heiko, et al.
Publicado: (2016)

Evidence for Involvement of GNB1L in Autism
por: Chen, Ying-Zhang, et al.
Publicado: (2012)

Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS
por: Boligan, Kayluz F., et al.
Publicado: (2020)

Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS
por: Oechtering, Johanna, et al.
Publicado: (2022)

GNB3 overexpression causes obesity and metabolic syndrome
por: Ozdemir, Alev Cagla, et al.
Publicado: (2017)

Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities
por: Rose, Natalie, et al.
Publicado: (2022)

Evaluation of Novel Platelet Polymorphisms in Stroke. Dichotomic Effect of rs5443 in GNB3
por: Martínez, Constantino, et al.
Publicado: (2015)

Haploinsufficiency as a disease mechanism in GNB1‐associated neurodevelopmental disorder
por: Schultz‐Rogers, Laura, et al.
Publicado: (2020)

Serum neurofilament light chains in MS: Association with the Timed Up and Go
por: Allali, Gilles, et al.
Publicado: (2020)

Combination of teriflunomide and interferon as follow-up therapy after fingolimod-associated PML
por: Fischer-Barnicol, Bettina, et al.
Publicado: (2020)

Mass Cytometry of CSF Identifies an MS-Associated B-cell Population
por: Johansson, David, et al.
Publicado: (2021)

A Splice Variant of GNB3 and Peripheral Polyneuropathy in Type 1 Diabetes
por: Chistiakov, Dimitry A., et al.
Publicado: (2009)

IS GNB3 C825T POLYMORPHISM ASSOCIATED WITH ELITE STATUS OF POLISH ATHLETES?
por: Sawczuk, M., et al.
Publicado: (2014)

Clinical and Neuroimaging Features in Charcot–Marie–Tooth Patients with GNB4 Mutations
por: Kwon, Hye Mi, et al.
Publicado: (2021)

Sensory regulation of absence seizures in a mouse model of Gnb1 encephalopathy
por: Teng, Sasa, et al.
Publicado: (2022)

CircGNB1 drives osteoarthritis pathogenesis by inducing oxidative stress in chondrocytes
por: Liang, Yi, et al.
Publicado: (2023)

Preserved Antigen-Specific Immune Response in Patients with Multiple Sclerosis Responding to IFNβ-Therapy
por: Mehling, Matthias, et al.
Publicado: (2013)

Development and Assessment of a Novel Predictive Nomogram to Predict the Risk of Secondary CR-GNB Bloodstream Infections among CR-GNB Carriers in the Gastroenterology Department: A Retrospective Case–Control Study
por: Zhang, Hongchen, et al.
Publicado: (2023)

Lymphocyte recovery after fingolimod discontinuation in patients with MS
por: Nagy, Sara, et al.
Publicado: (2020)

Glatiramer acetate immune modulates B-cell antigen presentation in treatment of MS
por: Häusler, Darius, et al.
Publicado: (2020)

Levofloxacin prophylaxis vs no prophylaxis in patients with neutropenia within an endemic country for carbapenem-resistant GNB
por: Clerici, Daniela, et al.
Publicado: (2022)

Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension
por: Nejatizadeh, Azim, et al.
Publicado: (2011)

Interactions between the FTO and GNB3 Genes Contribute to Varied Clinical Phenotypes in Hypertension
por: Kumar, Rahul, et al.
Publicado: (2013)

Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
por: Casiglia, Edoardo, et al.
Publicado: (2013)

Does the GNB3 C825T Polymorphism Influence Swimming Performance in Competitive Swimmers?
por: Grenda, Agata, et al.
Publicado: (2015)

Increased store-operated Ca(2+) entry mediated by GNB5 and STIM1
por: Kang, Namju, et al.
Publicado: (2018)

Encephalopathy-causing mutations in Gβ(1) (GNB1) alter regulation of neuronal GIRK channels
por: Reddy, Haritha P., et al.
Publicado: (2021)

Comparative analysis of dimethyl fumarate and fingolimod in relapsing–remitting multiple sclerosis
por: Lorscheider, Johannes, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j97igr5cae9g454h1fu6rq6uas