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The development of precision medicine in clinical practice

Precision medicine allows a dramatic expansion of biological data, while there is still an urgent need to understand and insight the exact meaning of those data to human health and disease. This has led to an increasing wealth of data unanalyzed. The concept of precision medicine is about the custom...

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Detalles Bibliográficos
Autores principales: He, Mingyan, Xia, Jinglin, Shehab, Mohamed, Wang, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547974/
https://www.ncbi.nlm.nih.gov/pubmed/26302883
http://dx.doi.org/10.1186/s40169-015-0069-y
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author He, Mingyan
Xia, Jinglin
Shehab, Mohamed
Wang, Xiangdong
author_facet He, Mingyan
Xia, Jinglin
Shehab, Mohamed
Wang, Xiangdong
author_sort He, Mingyan
collection PubMed
description Precision medicine allows a dramatic expansion of biological data, while there is still an urgent need to understand and insight the exact meaning of those data to human health and disease. This has led to an increasing wealth of data unanalyzed. The concept of precision medicine is about the customization of healthcare, with decisions and practices tailored to an individual patient based on their intrinsic biology in addition to clinical “signs and symptoms”. Construction of a standardized model for the integration of data from various platforms is the central mission of the ‘New Disease Management Model’. The model is helpful for the development of new taxonomy of diseases and subtypes, to personalize therapy based on patient genetic profiles. A rapid progression of precision therapy has been made recently. Clinical trials have shown the therapeutic efficacy of discovered and developed therapeutic agents has improved. However, next-generation drugs would be designed for disease subtypes with more specificity, efficacy and lower toxicity.
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spelling pubmed-45479742015-08-28 The development of precision medicine in clinical practice He, Mingyan Xia, Jinglin Shehab, Mohamed Wang, Xiangdong Clin Transl Med Editorial Precision medicine allows a dramatic expansion of biological data, while there is still an urgent need to understand and insight the exact meaning of those data to human health and disease. This has led to an increasing wealth of data unanalyzed. The concept of precision medicine is about the customization of healthcare, with decisions and practices tailored to an individual patient based on their intrinsic biology in addition to clinical “signs and symptoms”. Construction of a standardized model for the integration of data from various platforms is the central mission of the ‘New Disease Management Model’. The model is helpful for the development of new taxonomy of diseases and subtypes, to personalize therapy based on patient genetic profiles. A rapid progression of precision therapy has been made recently. Clinical trials have shown the therapeutic efficacy of discovered and developed therapeutic agents has improved. However, next-generation drugs would be designed for disease subtypes with more specificity, efficacy and lower toxicity. Springer Berlin Heidelberg 2015-08-25 /pmc/articles/PMC4547974/ /pubmed/26302883 http://dx.doi.org/10.1186/s40169-015-0069-y Text en © He et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Editorial
He, Mingyan
Xia, Jinglin
Shehab, Mohamed
Wang, Xiangdong
The development of precision medicine in clinical practice
title The development of precision medicine in clinical practice
title_full The development of precision medicine in clinical practice
title_fullStr The development of precision medicine in clinical practice
title_full_unstemmed The development of precision medicine in clinical practice
title_short The development of precision medicine in clinical practice
title_sort development of precision medicine in clinical practice
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547974/
https://www.ncbi.nlm.nih.gov/pubmed/26302883
http://dx.doi.org/10.1186/s40169-015-0069-y
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