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Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa
Hamster sperm hyperactivation is enhanced by progesterone, and this progesterone-enhanced hyperactivation is suppressed by 17β-estradiol (17βE(2)) and γ-aminobutyric acid (GABA). Although it has been indicated that melatonin also enhances hyperactivation, it is unknown whether melatonin-enhanced hyp...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Society for Reproduction and Development
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547986/ https://www.ncbi.nlm.nih.gov/pubmed/25959801 http://dx.doi.org/10.1262/jrd.2014-116 |
| Sumario: | Hamster sperm hyperactivation is enhanced by progesterone, and this progesterone-enhanced hyperactivation is suppressed by 17β-estradiol (17βE(2)) and γ-aminobutyric acid (GABA). Although it has been indicated that melatonin also enhances hyperactivation, it is unknown whether melatonin-enhanced hyperactivation is also suppressed by 17βE(2) and GABA. In the present study, melatonin-enhanced hyperactivation was significantly suppressed by 17βE(2) but not by GABA. Moreover, suppression of melatonin-enhanced hyperactivation by 17βE(2) occurred through non-genomic regulation via the estrogen receptor (ER). These results suggest that enhancement of hyperactivation is regulated by melatonin and 17βE(2) through non-genomic regulation. |
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