Cargando…
Effects of four-week feed restriction on toxicological parameters in beagle dogs
This study was conducted to examine any changes caused by feed restriction in dogs to contribute to safety evaluation in toxicity studies. Two male 7-month-old beagle dogs/group were fed 300 (control), 150 (50% of control), or 70 g/animal of diet daily (23% of control) for 4 weeks. Effects of feed r...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Association for Laboratory Animal Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548000/ https://www.ncbi.nlm.nih.gov/pubmed/25818481 http://dx.doi.org/10.1538/expanim.14-0098 |
_version_ | 1782387131852783616 |
---|---|
author | TAKAMATSU, Kazuhiko YAMASHITA, Hiroyuki SATAKE, Shigeru KAZUSA, Katsuyuki TABATA, Hajime NISHIKATA, Takahito |
author_facet | TAKAMATSU, Kazuhiko YAMASHITA, Hiroyuki SATAKE, Shigeru KAZUSA, Katsuyuki TABATA, Hajime NISHIKATA, Takahito |
author_sort | TAKAMATSU, Kazuhiko |
collection | PubMed |
description | This study was conducted to examine any changes caused by feed restriction in dogs to contribute to safety evaluation in toxicity studies. Two male 7-month-old beagle dogs/group were fed 300 (control), 150 (50% of control), or 70 g/animal of diet daily (23% of control) for 4 weeks. Effects of feed restriction, except for clinical signs, were noted depending on the feed dosage in almost all examinations. The principal outcomes were: decreased body weight and water consumption, ECG changes (decreased heart rate and prolonged QTc), and hematopoietic and lymphopoietic suppression (decreased reticulocyte ratio or white blood cell count in hematology, decreased nucleated cell count in bone marrow, decreased erythroid parameters in myelography, and hypocellularity of bone marrow and thymic atrophy in histopathology). In addition, some changes were noted in urinalysis (decreased urine volume and sodium and potassium excretion), blood chemistry (decreased ALP and inorganic phosphorus and increased creatinine), organ weights, and gastric histopathology. These results provide important reference data for distinguishing the primary effects of test compounds from secondary effects of decreased food consumption in toxicity studies in beagle dogs. |
format | Online Article Text |
id | pubmed-4548000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45480002015-08-26 Effects of four-week feed restriction on toxicological parameters in beagle dogs TAKAMATSU, Kazuhiko YAMASHITA, Hiroyuki SATAKE, Shigeru KAZUSA, Katsuyuki TABATA, Hajime NISHIKATA, Takahito Exp Anim Original This study was conducted to examine any changes caused by feed restriction in dogs to contribute to safety evaluation in toxicity studies. Two male 7-month-old beagle dogs/group were fed 300 (control), 150 (50% of control), or 70 g/animal of diet daily (23% of control) for 4 weeks. Effects of feed restriction, except for clinical signs, were noted depending on the feed dosage in almost all examinations. The principal outcomes were: decreased body weight and water consumption, ECG changes (decreased heart rate and prolonged QTc), and hematopoietic and lymphopoietic suppression (decreased reticulocyte ratio or white blood cell count in hematology, decreased nucleated cell count in bone marrow, decreased erythroid parameters in myelography, and hypocellularity of bone marrow and thymic atrophy in histopathology). In addition, some changes were noted in urinalysis (decreased urine volume and sodium and potassium excretion), blood chemistry (decreased ALP and inorganic phosphorus and increased creatinine), organ weights, and gastric histopathology. These results provide important reference data for distinguishing the primary effects of test compounds from secondary effects of decreased food consumption in toxicity studies in beagle dogs. Japanese Association for Laboratory Animal Science 2015-03-30 2015 /pmc/articles/PMC4548000/ /pubmed/25818481 http://dx.doi.org/10.1538/expanim.14-0098 Text en ©2015 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Original TAKAMATSU, Kazuhiko YAMASHITA, Hiroyuki SATAKE, Shigeru KAZUSA, Katsuyuki TABATA, Hajime NISHIKATA, Takahito Effects of four-week feed restriction on toxicological parameters in beagle dogs |
title | Effects of four-week feed restriction on toxicological parameters in beagle
dogs |
title_full | Effects of four-week feed restriction on toxicological parameters in beagle
dogs |
title_fullStr | Effects of four-week feed restriction on toxicological parameters in beagle
dogs |
title_full_unstemmed | Effects of four-week feed restriction on toxicological parameters in beagle
dogs |
title_short | Effects of four-week feed restriction on toxicological parameters in beagle
dogs |
title_sort | effects of four-week feed restriction on toxicological parameters in beagle
dogs |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548000/ https://www.ncbi.nlm.nih.gov/pubmed/25818481 http://dx.doi.org/10.1538/expanim.14-0098 |
work_keys_str_mv | AT takamatsukazuhiko effectsoffourweekfeedrestrictionontoxicologicalparametersinbeagledogs AT yamashitahiroyuki effectsoffourweekfeedrestrictionontoxicologicalparametersinbeagledogs AT satakeshigeru effectsoffourweekfeedrestrictionontoxicologicalparametersinbeagledogs AT kazusakatsuyuki effectsoffourweekfeedrestrictionontoxicologicalparametersinbeagledogs AT tabatahajime effectsoffourweekfeedrestrictionontoxicologicalparametersinbeagledogs AT nishikatatakahito effectsoffourweekfeedrestrictionontoxicologicalparametersinbeagledogs |